Study of brain perfusion in adults with Down syndrome along the Alzheimer's disease continuum

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-09-18 DOI:10.1002/alz.70581

Maria Franquesa-Mullerat, Alejandra O. Morcillo-Nieto, José Enrique Arriola-Infante, Sara E. Zsadanyi, Lídia Vaqué-Alcázar, Mateus Rozalem-Aranha, Javier Arranz, Íñigo Rodríguez-Baz, Lucia Maure-Blesa, Laura Videla, Isabel Barroeta, Laura Del Hoyo Soriano, Bessy Benejam, Susana Fernández, Aida Sanjuan Hernandez, Sandra Giménez, Daniel Alcolea, Olivia Belbin, Alberto Lleó, María Carmona-Iragui, Juan Fortea, Alexandre Bejanin

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引用次数: 0

Abstract

INTRODUCTION

We assessed pseudo-continuous arterial spin labeling (pCASL) sensitivity to detect changes in cerebral blood flow (CBF) in adults with Down syndrome (DS) along the Alzheimer's disease (AD) continuum and explored the similarity with sporadic AD (sAD) hypoperfusion profile.

METHODS

Fifty-one euploid cognitively unimpaired individuals, 54 adults with DS (34.54% symptomatic for AD), and 25 sAD patients underwent 3T magnetic resonance imaging. pCASL images were preprocessed using ASLprep. Analyses explored, globally and regionally, the effects of demographic variables, clinical stages, and AD biomarkers.

RESULTS

Age and sex differently impacted CBF in euploids versus the DS population. Asymptomatic DS showed temporo-parietal hypoperfusion, extending into frontal areas in symptomatic cases. This pattern closely resembled sAD's pattern and correlated with AD biomarkers.

DISCUSSION

Adults with DS present CBF changes before symptom onset, primarily affecting posterior regions as in sAD. pCASL is a sensitive imaging modality that captures early AD-related functional abnormalities in DS.

Highlights

Perfusion is negatively affected by age and correlates with Alzheimer's disease (AD) biomarkers in Down syndrome (DS).
Hypoperfusion in DS was observed even before the onset of the AD clinical symptoms.
The pattern of hypoperfusion in the DS population resembles the one observed in the sporadic AD population.

Abstract Image

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阿尔茨海默病连续体中唐氏综合征成人脑灌注的研究

我们评估了伪连续动脉自旋标记（pCASL）检测成人唐氏综合征（DS）患者阿尔茨海默病（AD）连续体脑血流量（CBF）变化的敏感性，并探讨了其与散发性AD （sAD）低灌注谱的相似性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.