Clinical study on autologous split-thickness skin graft combined with photodynamic therapy for the treatment of keloid in the female pubic region

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-09-15 DOI:10.1016/j.pdpdt.2025.105222

Wenyan Zhu , Xiaoyan Wu , Xuyan Weng , Xiaodong Yao , Xiaomei Cui , Mulan Fu , Xiaodong Chen

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引用次数: 0

Abstract

Objective

Keloid, marked by abnormal fibroblast activity and excessive collagen buildup, presents a therapeutic challenge due to their high recurrence rates. The pubic region, a sensitive anatomical area, is rarely discussed in keloid treatment literature. Our study demonstrates that autologous split-thickness skin grafting combined with topical photodynamic therapy(PDT) effectively prevents the recurrence of keloids in pubic region by radically eliminating inflammation and inhibiting fibroblast proliferation.

Methods

This study retrospectively analyzed 32 keloid patients treated with autologous split-thickness skin grafting and photodynamic therapy (surgery+PDT group) and compared them to a control group of 29 patients who underwent surgery alone (surgery only group). The improvement rate was evaluated at baseline (month 0) and at a 12-month follow-up (month 12) using the modified Vancouver Scar Scale (mVSS) and the Patient and Observer Scar Assessment Scale (POSAS)

Results

The study involved 61 patients. Both treatment groups exhibited significant enhancements in mVSS and POSAS scores; however, the combination therapy group showed a statistically significant improvement in POSAS scores at 12 months compared to the surgery-only group.

Conclusion

Patients receiving both surgery and PDT showed a significantly higher improvement rate compared to those undergoing surgery alone.

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自体裂厚皮肤移植联合光动力治疗女性阴部瘢痕疙瘩的临床研究。

目的：瘢痕疙瘩以成纤维细胞活性异常和胶原堆积过多为特征，因其高复发率而成为治疗的挑战。阴部是一个敏感的解剖区域，在瘢痕疙瘩治疗文献中很少被讨论。我们的研究表明自体裂厚皮肤移植联合局部光动力治疗（PDT）可以从根本上消除炎症和抑制成纤维细胞增殖，有效地预防阴部瘢痕疙瘩的复发。方法：回顾性分析32例瘢痕瘤患者行自体裂厚皮移植术和光动力治疗（手术+PDT组），并与对照组29例单纯手术（手术组）进行比较。在基线（第0个月）和12个月的随访（第12个月）中，使用改进的温哥华疤痕量表（mVSS）和患者和观察者疤痕评估量表（POSAS）评估改善率。结果：研究涉及61例患者。两个治疗组的mVSS和POSAS评分均有显著提高；然而，与单纯手术组相比，联合治疗组在12个月时的POSAS评分有统计学上的显著改善。结论：手术加PDT治疗的患者较单纯手术治疗的患者有明显提高的治愈率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.