Comparative analysis of shear wave elastography and biaxial testing for accurate soft tissue mechanical assessment

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-09-13 DOI:10.1016/j.jmbbm.2025.107204

Zachary Ross , Gregory Hirst , Adam Rose , North Graff , Christopher R. Dillon , Benjamin Terry

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引用次数: 0

Abstract

Objective

This study aims to validate the efficacy of shear wave elastography for biomedical research by demonstrating its ability to accurately and non-destructively characterize tissue stiffness in-situ. While this study validated a specific device, the underlying physical principle - shear wave propagation speed for stiffness measurement - suggests these results should generalize to other shear wave elastography systems operating with similar specifications and measurement protocols.

Methods

To validate the ability of the shear wave elastography function to measure absolute tissue stiffness at low strains, porcine intestinal tissue samples were embedded in saline-infused gelatin and assessed for stiffness using the ultrasound machine. Samples also underwent traditional biaxial tensile testing, allowing for a direct comparison of stiffness values between the two methods.

Results

Stiffness values at low strains produced by shear wave elastography were not statistically different from values produced by traditional biaxial testing.

Conclusion

Shear wave elastography can accurately and non-destructively measure stiffness values of soft tissue at low strains comparable to traditional destructive testing methods.

Significance

By employing these methodologies and comparative analyses, this study contributes to establishing the credibility and utility of shear wave elastography in biomedical research and quantitative clinical therapeutics, affirming its potential for in-situ tissue stiffness characterization and accurate mechanical property assessment.

查看原文本刊更多论文

剪切波弹性成像与双轴试验的比较分析，以准确评估软组织力学。

目的：本研究旨在验证横波弹性成像在生物医学研究中的有效性，证明其能够准确、无损地原位表征组织刚度。虽然这项研究验证了一个特定的设备，但潜在的物理原理-用于刚度测量的剪切波传播速度-表明这些结果应该推广到具有类似规格和测量方案的其他剪切波弹性成像系统。方法：为了验证剪切波弹性函数在低应变下测量绝对组织刚度的能力，将猪肠组织样品包埋在盐水注入的明胶中，并使用超声仪评估其刚度。样品还进行了传统的双轴拉伸测试，允许直接比较两种方法之间的刚度值。结果：剪切波弹性图得到的低应变刚度值与传统双轴试验得到的刚度值无统计学差异。结论：与传统的破坏性检测方法相比，横波弹性成像可以准确、无损地测量软组织在低应变下的刚度值。意义：通过采用这些方法和对比分析，本研究有助于建立剪切波弹性成像在生物医学研究和定量临床治疗中的可信度和实用性，肯定其在原位组织刚度表征和准确力学性能评估方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.