Randomized contralateral eye study of myopia control between aspheric multifocal soft contact lens and orthokeratology in children.

IF 3.7 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye Pub Date : 2025-09-16 DOI:10.1016/j.clae.2025.102508

Ruru Chen, Tianhui Chen, Weiwei Lu, Yue Li, Jiawei Li, Tiankun Li, Hengli Lian, Siping Chen, Colm McAlinden, Xiaoying Wang, Jinhai Huang

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引用次数: 0

Abstract

Background: This study aimed to compare myopia progression in children wearing an aspheric multifocal contact lens and an orthokeratology (OrthoK) lens.

Methods: A total of 65 participants, aged 9.70 ± 1.31 years, were fitted with an OrthoK lens in one randomly assigned eye and a multifocal soft contact lens in the contralateral eye for the first 6 months (period 1). Following this, contact lens wear was discontinued in both eyes for 1 month, after which the two lens-wearing methods were swapped between eyes and continued for another 6 months (period 2). Axial length (AL), spherical equivalent refraction (SER), central corneal thickness (CCT), and central choroidal thickness (CChT) were measured at the 0-, 6-, 7-, 13-, and 14-month visits. AL and SER were the primary outcome measures.

Results: For the OrthoK and multifocal soft lens, AL elongation was 0.14 ± 0.11 mm and 0.23 ± 0.12 mm, respectively, after period 1. AL elongation for the OrthoK and multifocal lens was 0.12 ± 0.19 mm and 0.20 ± 0.13 mm, respectively, after period 2. The SER change for the OrthoK and multifocal lens was -0.20 ± 0.27 D and -0.33 ± 0.30 D after period 1 and -0.26 ± 0.40 D and -0.36 ± 0.46 D after period 2, respectively. No significant differences were observed between the two treatment groups (all P > 0.05).

Conclusions: During the 14-month observation period, no statistically significant differences in myopia progression were found between the aspheric multifocal contact lens and the OrthoK lens. Further longitudinal observation is necessary to characterize the disparities in long-term myopia-control efficacy between the two intervention strategies.

Trial registration: ChiCTR, ChiCTR2000041520. Registered 27 December 2020, https://www.chictr.org.cn/ChiCTR2000041520. Retrospectively registered.

查看原文本刊更多论文

非球面多焦点软性接触镜与角膜塑形术对儿童近视控制的随机对侧眼研究。

背景：本研究旨在比较儿童配戴非球面多焦点隐形眼镜和角膜塑形镜（OrthoK）的近视进展。方法：65名参与者，年龄9.70±1.31岁，在前6个月（第一阶段）随机选择一只眼配戴OrthoK晶状体，对侧眼配戴多焦软性接触镜。在此之后，两只眼睛停止佩戴隐形眼镜一个月，之后在两只眼睛之间交换两种隐形眼镜佩戴方式，并继续佩戴6个月（第二阶段）。在第0、6、7、13和14个月随访时测量轴长（AL）、球面等效屈光度（SER）、角膜中央厚度（CCT）和脉络膜中央厚度（CChT）。AL和SER是主要结局指标。结果：对于OrthoK和多焦软性晶状体，第1期后AL伸长分别为0.14±0.11 mm和0.23±0.12 mm。第2期后，OrthoK和多焦晶状体的AL延伸率分别为0.12±0.19 mm和0.20±0.13 mm。OrthoK和多焦晶状体的SER变化在第1周期后分别为-0.20±0.27 D和-0.33±0.30 D，在第2周期后分别为-0.26±0.40 D和-0.36±0.46 D。两组间比较差异无统计学意义（P < 0.05）。结论：在14个月的观察期内，非球面多焦点隐形眼镜与OrthoK隐形眼镜的近视进展无统计学差异。进一步的纵向观察是必要的，以表征两种干预策略之间长期近视控制效果的差异。试验注册号：ChiCTR， ChiCTR2000041520。2020年12月27日注册，https://www.chictr.org.cn/ChiCTR2000041520。回顾注册。

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来源期刊

Contact Lens & Anterior Eye OPHTHALMOLOGY-

CiteScore

7.60

自引率

18.80%

发文量

198

审稿时长

55 days

期刊介绍： Contact Lens & Anterior Eye is a research-based journal covering all aspects of contact lens theory and practice, including original articles on invention and innovations, as well as the regular features of: Case Reports; Literary Reviews; Editorials; Instrumentation and Techniques and Dates of Professional Meetings.