[Feasibility study on the clinical translation of a remote jaundice monitoring system for home-based screening of neonatal hyperbilirubinemia].

Q3 Medicine

中国当代儿科杂志 Pub Date : 2025-07-15 DOI:10.7499/j.issn.1008-8830.2503110

Xiao-Fan Sun, Yi Zheng, Ai-Ling Su, Shu-Ping Han, Xiao-Yue Dong

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引用次数: 0

Abstract

Objectives: To evaluate the clinical utility and translational potential of a remote jaundice monitoring system for home-based screening of neonatal hyperbilirubinemia.

Methods: A prospective self-controlled study was conducted, enrolling 538 newborns with gestational age ≥35 weeks, birth weight ≥2 000 g, and postnatal age ≤14 days at the Women's Hospital of Nanjing Medical University from March to October 2023. Four screening protocols with different predictive indicators were developed based on the Chinese Neonatal Transcutaneous Hourly Bilirubin Nomogram. The effectiveness of the system was evaluated, and the feasibility of using the remote jaundice monitoring system in actual home settings was analyzed.

Results: A total of 538 paired transcutaneous bilirubin (TcB) and total serum bilirubin (TSB) measurements showed a strong correlation (r=0.85, P<0.001), with 95.0% (511/538) of samples within the 95% limits of agreement. Using TcB ≥ the 95th percentile as the predictive indicator, the system achieved 100% sensitivity, 46.2% specificity, and an area under the receiver operating characteristic curve of 0.731 (95%CI: 0.682-0.780). This approach could reduce unnecessary hospital visits by 41.4% (221/538).

Conclusions: The system integrates the QBH-801 transcutaneous bilirubinometer, intelligent early warning, and remote guidance services, establishing a closed-loop "hospital-to-home" management model. It demonstrates high safety and feasibility, with significant clinical translational value.

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[远程黄疸监测系统用于新生儿高胆红素血症家庭筛查的临床转化可行性研究]。

目的：评估远程黄疸监测系统在新生儿高胆红素血症家庭筛查中的临床应用和转化潜力。方法：采用前瞻性自我对照研究，于2023年3月至10月在南京医科大学附属妇产医院出生的538例胎龄≥35周、出生体重≥2 000 g、出生年龄≤14天的新生儿。基于中国新生儿经皮每小时胆红素图，制定了四种具有不同预测指标的筛查方案。评估了系统的有效性，并分析了在实际家庭环境中使用远程黄疸监测系统的可行性。结果：538对经皮胆红素（TcB）与血清总胆红素（TSB）测量结果有很强的相关性（r=0.85, PCI: 0.682-0.780）。这种方法可以减少41.4%（221/538）不必要的医院就诊。结论：该系统集成了QBH-801经皮胆红素计、智能预警和远程指导服务，建立了“医院到家庭”的闭环管理模式。具有较高的安全性和可行性，具有重要的临床转化价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国当代儿科杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

1.50

自引率

0.00%

发文量

5006

期刊介绍： The Chinese Journal of Contemporary Pediatrics (CJCP) is a peer-reviewed open access periodical in the field of pediatrics that is sponsored by the Central South University/Xiangya Hospital of Central South University and under the auspices of the Ministry of Education of China. It is cited as a source in the scientific and technological papers of Chinese journals, the Chinese Science Citation Database (CSCD), and is one of the core Chinese periodicals in the Peking University Library. CJCP has been indexed by MEDLINE/PubMed/PMC of the American National Library, American Chemical Abstracts (CA), Holland Medical Abstracts (EM), Western Pacific Region Index Medicus (WPRIM), Scopus and EBSCO. It is a monthly periodical published on the 15th of every month, and is distributed both at home and overseas. The Chinese series publication number is CN 43-1301/R；ISSN 1008-8830. The tenet of CJCP is to “reflect the latest advances and be open to the world”. The periodical reports the most recent advances in the contemporary pediatric field. The majority of the readership is pediatric doctors and researchers.