[Dynamic changes in serum microRNA-15b and vascular endothelial growth factor in preterm infants with bronchopulmonary dysplasia and their value in assessing neurodevelopment].

Q3 Medicine

中国当代儿科杂志 Pub Date : 2025-07-15 DOI:10.7499/j.issn.1008-8830.2412039

Qian Chen, Pei-Pei Zhang, Qing-Hua Lu, Zhen-Xia Wan, Lei Huang

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引用次数: 0

Abstract

Objectives: To investigate the dynamic changes in serum microRNA-15b (miR-15b) and vascular endothelial growth factor (VEGF) in preterm infants with mild or moderate-to-severe bronchopulmonary dysplasia (BPD), as well as their value in assessing short-term neurodevelopment.

Methods: A retrospective analysis was conducted on the medical data of 156 preterm infants with BPD who were admitted to the neonatal intensive care unit from January 2020 to February 2023. According to the severity of BPD, they were divided into a mild group (n=88) and a moderate-to-severe group (n=68). Serum levels of miR-15b and VEGF were measured on postnatal days 1, 7, 14, and 28. Repeated measures analysis of variance was used to assess the dynamic changes in serum levels of miR-15b and VEGF. The mediating effect of VEGF between miR-15b and short-term neurological development was tested and analyzed using the stepwise regression method and the Bootstrap method. Logistic regression analysis was used to identify factors influencing adverse neurodevelopmental outcomes.

Results: In the mild group, there was a significant reduction in the serum level of miR-15b and a significant increase in VEGF over time (P<0.05), while in the moderate-to-severe group, there was a significant increase in miR-15b and a significant reduction in VEGF over time (P<0.05). Serum miR-15b and VEGF levels were important factors influencing neurodevelopmental outcomes, showing independent correlations (P<0.001). The mediating effect analysis indicated that miR-15b indirectly affected short-term neurodevelopment by inhibiting VEGF expression [indirect effect: -0.705 (95%CI: -1.178 to -0.372)], with the indirect effect accounting for 54.36% of the total effect.

Conclusions: There are different changing trends in serum levels of miR-15b and VEGF in preterm infants with mild and moderate-to-severe BPD. miR-15b primarily influences neurodevelopment through VEGF.

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[支气管肺发育不良早产儿血清microRNA-15b和血管内皮生长因子的动态变化及其在神经发育评估中的价值]。

目的：探讨轻度或中重度支气管肺发育不良（BPD）早产儿血清miR-15b （miR-15b）和血管内皮生长因子（VEGF）的动态变化及其在短期神经发育评估中的价值。方法：回顾性分析2020年1月至2023年2月新生儿重症监护病房收治的156例BPD早产儿的医疗资料。根据BPD的严重程度分为轻度组（n=88）和中重度组（n=68）。在出生后第1、7、14和28天检测血清miR-15b和VEGF水平。采用重复测量方差分析评估血清miR-15b和VEGF水平的动态变化。采用逐步回归法和Bootstrap法对VEGF在miR-15b与短期神经发育之间的中介作用进行检验和分析。采用Logistic回归分析确定影响不良神经发育结局的因素。结果：轻度组随时间推移血清miR-15b水平显著降低，VEGF水平显著升高（PPPCI: -1.178 ~ -0.372），间接效应占总效应的54.36%。结论：轻度和中重度BPD早产儿血清miR-15b、VEGF水平变化趋势不同。miR-15b主要通过VEGF影响神经发育。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国当代儿科杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

1.50

自引率

0.00%

发文量

5006

期刊介绍： The Chinese Journal of Contemporary Pediatrics (CJCP) is a peer-reviewed open access periodical in the field of pediatrics that is sponsored by the Central South University/Xiangya Hospital of Central South University and under the auspices of the Ministry of Education of China. It is cited as a source in the scientific and technological papers of Chinese journals, the Chinese Science Citation Database (CSCD), and is one of the core Chinese periodicals in the Peking University Library. CJCP has been indexed by MEDLINE/PubMed/PMC of the American National Library, American Chemical Abstracts (CA), Holland Medical Abstracts (EM), Western Pacific Region Index Medicus (WPRIM), Scopus and EBSCO. It is a monthly periodical published on the 15th of every month, and is distributed both at home and overseas. The Chinese series publication number is CN 43-1301/R；ISSN 1008-8830. The tenet of CJCP is to “reflect the latest advances and be open to the world”. The periodical reports the most recent advances in the contemporary pediatric field. The majority of the readership is pediatric doctors and researchers.