Unlocking Mysteries: Exploring the Dynamic Interplay Among Sleep, the Immune System, and Curcumin in Contemporary Research.

IF 1.8 Q4 CLINICAL NEUROLOGY
Sleep Science Pub Date : 2025-03-27 eCollection Date: 2025-09-01 DOI:10.1055/s-0045-1802321
Rohit Kumar, Atul Pandey, Arpana Vibhuti, Manzoor Ali, Chung-Ming Chang, Ramendra Pati Pandey
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Abstract

The scientific disciplines encompassing sleep, the immune system, and curcumin have garnered considerable interest due to their interconnectedness and potential implications for human health. Sleep is a crucial factor in maintaining optimal immune function, as it facilitates the release of cytokines, which are signaling molecules responsible for regulating immune responses. On the contrary, sleep deprivation has the potential of inhibiting immune function, thereby heightening the susceptibility to infection and disease. Curcumin, a naturally occurring polyphenol derived from the turmeric plant, has been observed to possess immunomodulatory characteristics through its ability to modulate the equilibrium between pro- and anti-inflammatory cytokines. It is worth noting that there is evidence suggesting that curcumin supplementation could enhance the quality of sleep. Scientific studies have indicated that curcumin supplementation has been associated with an increase in the duration of sleep and a decrease in wakefulness among individuals who are in good health. Additionally, curcumin supplementation has been found to enhance sleep quality and alleviate symptoms of depression in individuals diagnosed with major depressive disorder. The intricate interplay among sleep, the immune system, and curcumin is multifaceted, and scientific investigations indicate that curcumin may serve as a beneficial dietary adjunct to enhance immune function and optimize sleep quality. Nevertheless, additional investigation is required to fully comprehend the mechanisms through which curcumin alters the immune system and enhances sleep, as well as to ascertain the most effective dose and timing of curcumin supplementation.

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解开谜团:探索当代研究中睡眠、免疫系统和姜黄素之间的动态相互作用。
包括睡眠、免疫系统和姜黄素在内的科学学科因其相互联系和对人类健康的潜在影响而引起了相当大的兴趣。睡眠是维持最佳免疫功能的关键因素,因为它促进细胞因子的释放,细胞因子是负责调节免疫反应的信号分子。相反,睡眠不足有可能抑制免疫功能,从而增加对感染和疾病的易感性。姜黄素是一种从姜黄植物中提取的天然多酚,已被观察到通过调节促炎性和抗炎性细胞因子之间的平衡而具有免疫调节特性。值得注意的是,有证据表明补充姜黄素可以提高睡眠质量。科学研究表明,在健康状况良好的人群中,补充姜黄素与睡眠时间的增加和清醒时间的减少有关。此外,姜黄素补充剂已被发现可以提高睡眠质量,减轻重度抑郁症患者的抑郁症状。睡眠、免疫系统和姜黄素之间错综复杂的相互作用是多方面的,科学研究表明,姜黄素可能是一种有益的饮食辅助物,可以增强免疫功能和优化睡眠质量。然而,需要进一步的研究来充分了解姜黄素改变免疫系统和增强睡眠的机制,以及确定姜黄素补充的最有效剂量和时间。
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来源期刊
Sleep Science
Sleep Science CLINICAL NEUROLOGY-
CiteScore
2.50
自引率
12.50%
发文量
124
审稿时长
10 weeks
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