{"title":"Research Review on the Mechanisms of Pathological New Bone Formation in Ankylosing Spondylitis.","authors":"Xingshun Zhou, Wenhui Ma, Hengsheng Zhang, Zilin Zhao, Cong Huang","doi":"10.2147/ORR.S540714","DOIUrl":null,"url":null,"abstract":"<p><p>Ankylosing spondylitis (AS) is a long-lasting autoimmune disorder marked by inflammatory processes affecting the spinal column and sacroiliac joints, alongside abnormal bone growth. This review aims to summarize the mechanisms underlying pathological new bone formation in AS, focusing on key cell types, molecular pathways, and their roles in disease progression. We will discuss the interplay between osteoblasts and osteoclasts, the cytokines and signaling pathways that influence new bone formation, and how recent research findings contribute to our understanding of this complex process. Through a comprehensive analysis of relevant literature, this review seeks to provide a theoretical foundation and direction for future therapeutic strategies.</p>","PeriodicalId":19608,"journal":{"name":"Orthopedic Research and Reviews","volume":"17 ","pages":"469-479"},"PeriodicalIF":2.3000,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439829/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Orthopedic Research and Reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/ORR.S540714","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ORTHOPEDICS","Score":null,"Total":0}
引用次数: 0
Abstract
Ankylosing spondylitis (AS) is a long-lasting autoimmune disorder marked by inflammatory processes affecting the spinal column and sacroiliac joints, alongside abnormal bone growth. This review aims to summarize the mechanisms underlying pathological new bone formation in AS, focusing on key cell types, molecular pathways, and their roles in disease progression. We will discuss the interplay between osteoblasts and osteoclasts, the cytokines and signaling pathways that influence new bone formation, and how recent research findings contribute to our understanding of this complex process. Through a comprehensive analysis of relevant literature, this review seeks to provide a theoretical foundation and direction for future therapeutic strategies.
期刊介绍：
Orthopedic Research and Reviews is an international, peer-reviewed, open-access journal focusing on the patho-physiology of the musculoskeletal system, trauma, surgery and other corrective interventions to restore mobility and function. Advances in new technologies, materials, techniques and pharmacological agents will be particularly welcome. Specific topics covered in the journal include: Patho-physiology and bioengineering, Technologies and materials science, Surgical techniques, including robotics, Trauma management and care, Treatment including pharmacological and non-pharmacological, Rehabilitation and Multidisciplinarian care approaches, Patient quality of life, satisfaction and preference, Health economic evaluations. The journal welcomes submitted papers covering original research, basic science and technology, clinical studies, reviews and evaluations, guidelines, expert opinion and commentary, case reports and extended reports.
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