Associations of diet-derived short chain fatty acids with Parkinson's disease: a systematic review and meta-analysis.

IF 3.6 4区医学 Q2 NEUROSCIENCES

Nutritional Neuroscience Pub Date : 2025-09-17 DOI:10.1080/1028415X.2025.2558119

Ke An, Yi Qu, Jingyi Li, Danlei Wang, Zhijuan Mao, Zheng Xue

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引用次数: 0

Abstract

Objectives: As extensively researched metabolites, short chain fatty acids (SCFAs) undergo significant alterations in individuals with Parkinson's disease (PD). This meta-analysis was conducted to (1) explore the relationship between SCFAs and PD, and (2) provide evidence for the metabolic mechanisms underlying PD pathogenesis.

Methods: A systematic search of four electronic databases (PubMed, Embase, Web of Science and Cochrane Library) was conducted up to February 29, 2024. The Agency of Healthcare Research and Quality (AHRQ) criteria were used for quality evaluation. Forest plots were used to display the results of the meta-analysis, and publication bias was assessed using funnel plots, Begg's tests and Egger's tests. Sensitivity analysis revealed heterogeneous sources among the included studies.

Results: A total of 9 independent studies were enrolled, including 485 PD patients and 338 controls. In this meta-analysis, we discovered that, in comparison to healthy controls, stool acetic (SMD: -0.80; 95% CI: -1.23, -0.37), butyric (SMD: -0.71; 95% CI: -1.19, -0.24) and propionic acids (SMD: -0.98; 95% CI: -1.57, -0.40) were decreased, while plasma butyric (SMD: 0.25; 95% CI: 0.05, 0.44), isobutyric (SMD: 0.35, 95% CI: 0.11, 0.59) and propionic acids (SMD: 0.37, 95% CI: 0.16, 0.58) were increased in PD patients. Other SCFAs were not significantly different between the two groups.

Conclusions: The evidence from this meta-analysis demonstrates that the stool and plasma SCFAs of PD patients are distinct from those of the control group. This study highlights SCFAs' potential importance as novel interventional targets.

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饮食来源的短链脂肪酸与帕金森病的关系：一项系统综述和荟萃分析

目的：作为广泛研究的代谢物，短链脂肪酸（SCFAs）在帕金森病（PD）患者中发生显著改变。本荟萃分析旨在(1)探索SCFAs与PD之间的关系；(2)为PD发病机制的代谢机制提供证据。方法：系统检索截至2024年2月29日的PubMed、Embase、Web of Science和Cochrane Library四个电子数据库。采用卫生保健研究和质量机构（AHRQ）标准进行质量评价。使用森林图显示meta分析的结果，并使用漏斗图、Begg检验和Egger检验评估发表偏倚。敏感性分析显示在纳入的研究中存在异质性来源。结果：共纳入9项独立研究，包括485例PD患者和338例对照。在这项荟萃分析中，我们发现，与健康对照相比，PD患者的粪便乙酸（SMD: -0.80; 95% CI: -1.23, -0.37）、丁酸（SMD: -0.71; 95% CI: -1.19, -0.24）和丙酸（SMD: -0.98; 95% CI: -1.57, -0.40）降低，而血浆丁酸（SMD: 0.25; 95% CI: 0.05, 0.44）、异丁酸（SMD: 0.35, 95% CI: 0.11, 0.59）和丙酸（SMD: 0.37, 95% CI: 0.16, 0.58）升高。其他scfa在两组间无显著差异。结论：本荟萃分析的证据表明，PD患者的粪便和血浆SCFAs与对照组不同。本研究强调了scfa作为新型介入靶点的潜在重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutritional Neuroscience 医学-神经科学

CiteScore

8.50

自引率

2.80%

发文量

236

审稿时长

>12 weeks

期刊介绍： Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.