Vitamin D receptor expression level in patients with SLE and its relationship with vitamin D status, disease course and bone mineral density.

IF 3.5 2区 医学 Q1 RHEUMATOLOGY
Sergii Shevchuk, Tetiana Malovana, Liubov Marynych, Liudmyla Denyshchych
{"title":"Vitamin D receptor expression level in patients with SLE and its relationship with vitamin D status, disease course and bone mineral density.","authors":"Sergii Shevchuk, Tetiana Malovana, Liubov Marynych, Liudmyla Denyshchych","doi":"10.1136/lupus-2025-001730","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To determine vitamin D receptor (VDR) blood serum concentrations in patients with SLE and to assess the relationship with vitamin D status, disease course, bone turnover markers levels and bone mineral density (BMD).</p><p><strong>Methods: </strong>The cross-sectional study involved 99 patients with SLE and 30 controls. We assessed VDR, vitamin D, C-reactive protein (CRP), interleukin (IL) 6, osteocalcin (OC), C-terminal telopeptide of type I collagen (CTX) concentrations, and erythrocyte sedimentation rate (ESR) in study subjects. Dual-energy X-ray absorptiometry was also performed.</p><p><strong>Results: </strong>Mean VDR levels in patients with SLE and in the control group were 12.78±0.61 ng/mL and 23.12±0.61 ng/mL, accordingly (p<0.01). 77.8% patients with SLE had low VDR concentrations and only 22.2% patients presented relatively normal or high levels. Low VDR levels in patients with SLE were associated with age (p=0.054, r=-0.22). The study did not reveal a relationship between VDR level and sex, disease duration, body mass index (BMI) and cumulative glucocorticoid (GC) dose. No association was found between VDR level and a diagnosed lupus nephritis, creatinine concentration and glomerular filtration rate. The correlation analysis confirmed the association of low VDR level with high disease activity, namely with elevated CRP (r=-0.22), IL-6 (r=-0.21) levels, SLE Disease Activity Index 2000 variant (r=-0.20). VDR concentration was closely associated with vitamin D supply. The average level of vitamin D in patients with low VDR was 33.55% lower than in the group with a relatively normal vitamin concentration (p=0.0001, r=0.47). We revealed a proportional increase of CTX concentration associated with VDR decrease (p<0.05, r=-0.27). No significant difference in average Z-score, T-score and BMD between the groups of patients with SLE with low and relatively normal VDR levels (p>0.05) was found.</p><p><strong>Conclusion: </strong>Low VDR concentration is a common phenomenon in patients with SLE associated with age, high disease activity, vitamin D supply and serum CTX concentration. VDR concentration had no significant association with sex, disease duration, cumulative GC dose, BMI, a diagnosed lupus nephritis, Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index, OC level and BMD.</p>","PeriodicalId":18126,"journal":{"name":"Lupus Science & Medicine","volume":"12 2","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12443211/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lupus Science & Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/lupus-2025-001730","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: To determine vitamin D receptor (VDR) blood serum concentrations in patients with SLE and to assess the relationship with vitamin D status, disease course, bone turnover markers levels and bone mineral density (BMD).

Methods: The cross-sectional study involved 99 patients with SLE and 30 controls. We assessed VDR, vitamin D, C-reactive protein (CRP), interleukin (IL) 6, osteocalcin (OC), C-terminal telopeptide of type I collagen (CTX) concentrations, and erythrocyte sedimentation rate (ESR) in study subjects. Dual-energy X-ray absorptiometry was also performed.

Results: Mean VDR levels in patients with SLE and in the control group were 12.78±0.61 ng/mL and 23.12±0.61 ng/mL, accordingly (p<0.01). 77.8% patients with SLE had low VDR concentrations and only 22.2% patients presented relatively normal or high levels. Low VDR levels in patients with SLE were associated with age (p=0.054, r=-0.22). The study did not reveal a relationship between VDR level and sex, disease duration, body mass index (BMI) and cumulative glucocorticoid (GC) dose. No association was found between VDR level and a diagnosed lupus nephritis, creatinine concentration and glomerular filtration rate. The correlation analysis confirmed the association of low VDR level with high disease activity, namely with elevated CRP (r=-0.22), IL-6 (r=-0.21) levels, SLE Disease Activity Index 2000 variant (r=-0.20). VDR concentration was closely associated with vitamin D supply. The average level of vitamin D in patients with low VDR was 33.55% lower than in the group with a relatively normal vitamin concentration (p=0.0001, r=0.47). We revealed a proportional increase of CTX concentration associated with VDR decrease (p<0.05, r=-0.27). No significant difference in average Z-score, T-score and BMD between the groups of patients with SLE with low and relatively normal VDR levels (p>0.05) was found.

Conclusion: Low VDR concentration is a common phenomenon in patients with SLE associated with age, high disease activity, vitamin D supply and serum CTX concentration. VDR concentration had no significant association with sex, disease duration, cumulative GC dose, BMI, a diagnosed lupus nephritis, Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index, OC level and BMD.

SLE患者维生素D受体表达水平及其与维生素D状态、病程和骨密度的关系
目的:测定SLE患者血清维生素D受体(VDR)浓度,并探讨其与维生素D状态、病程、骨转换标志物水平和骨密度(BMD)的关系。方法:横断面研究纳入99例SLE患者和30例对照。我们评估了研究对象的VDR、维生素D、c反应蛋白(CRP)、白细胞介素(IL) 6、骨钙素(OC)、I型胶原c端端肽(CTX)浓度和红细胞沉降率(ESR)。同时进行双能x线吸收测定。结果:SLE患者与对照组VDR平均水平分别为12.78±0.61 ng/mL和23.12±0.61 ng/mL,差异有统计学意义(p0.05)。结论:低VDR浓度是SLE患者的常见现象,与年龄、疾病活动度、维生素D供应和血清CTX浓度有关。VDR浓度与性别、病程、累积GC剂量、BMI、诊断狼疮肾炎、系统性狼疮国际合作诊所/美国风湿病学会损伤指数、OC水平和BMD无显著相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Lupus Science & Medicine
Lupus Science & Medicine RHEUMATOLOGY-
CiteScore
5.30
自引率
7.70%
发文量
88
审稿时长
15 weeks
期刊介绍: Lupus Science & Medicine is a global, peer reviewed, open access online journal that provides a central point for publication of basic, clinical, translational, and epidemiological studies of all aspects of lupus and related diseases. It is the first lupus-specific open access journal in the world and was developed in response to the need for a barrier-free forum for publication of groundbreaking studies in lupus. The journal publishes research on lupus from fields including, but not limited to: rheumatology, dermatology, nephrology, immunology, pediatrics, cardiology, hepatology, pulmonology, obstetrics and gynecology, and psychiatry.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信