Frequency-dependent and temporal variability of low-frequency fluctuations in patients with primary Sjögren's syndrome.

IF 3.5 2区 医学 Q1 RHEUMATOLOGY
Chunfeng Hu, Luoyu Wang, Xiuhong Ge, Zhijiang Han, Xiaofang Zhang, Xinyun Du, Yushan Shang, Huijun Cao, Chengcheng Gao, Peiying Wei, Jiao Huang
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引用次数: 0

Abstract

Objectives: The central nervous system is a significant extraglandular target in primary Sjögren's syndrome (pSS), often characterised by cognitive deficits. However, the underlying mechanisms remain elusive. This study aims to investigate the alterations in amplitude of low-frequency fluctuations (ALFF) in patients with pSS and to explore whether it exhibits frequency dependence and temporal variability, attempting to explore its mechanism.

Methods: The study comprised 68 patients with pSS and 69 healthy controls, all of whom underwent resting-state functional MRI and neuropsychological assessments. The ALFF method was used to ascertain whether frequency-dependent alterations occur within the slow-5 (0.01-0.027 Hz) and slow-4 (0.027-0.073 Hz) frequency bands. Additionally, dynamic ALFF (dALFF) analysis was conducted to explore the temporal variability. Ultimately, the correlation between the abnormal brain regions and neuropsychological assessments was elucidated.

Results: The right fusiform gyrus of patients with pSS shows abnormalities in ALFF and its two sub-bands, while the left precentral gyrus and right middle frontal gyrus exhibited abnormal increase limited to the slow-5 frequency band. dALFF showed an abnormal activity in the left supplementary motor area in patients with pSS. Additionally, the differential brain regions identified by the slow-5 frequency band of ALFF correlated with certain neuropsychological scales.

Conclusions: This research indicates that ALFF metrics offer enhanced insights into the alterations of regional brain function in patients with pSS, which exhibits both frequency-dependent and temporal variability characteristics, complementing traditional metrics and enhancing our comprehension of brain function in pSS and suggests that ALFF may emerge as a novel instrument for exploring the underlying neural mechanisms in patients with pSS.

Abstract Image

Abstract Image

原发性Sjögren综合征患者低频波动的频率依赖性和时间变异性
目的:中枢神经系统是原发性Sjögren综合征(pSS)的一个重要的腺外靶点,通常以认知缺陷为特征。然而,潜在的机制仍然难以捉摸。本研究旨在探讨pSS患者低频波动幅度(ALFF)的变化,并探讨其是否具有频率依赖性和时间变异性,试图探讨其机制。方法:研究纳入68例pSS患者和69名健康对照者,所有患者均接受静息状态功能MRI和神经心理学评估。ALFF方法用于确定频率相关的变化是否发生在慢5 (0.01-0.027 Hz)和慢4 (0.027-0.073 Hz)频段内。此外,还进行了动态ALFF (dALFF)分析,以探讨时间变异。最后,阐明了异常脑区与神经心理学评估之间的相关性。结果:pSS患者右侧梭状回ALFF及其两个亚带出现异常,左侧中央前回和右侧额中回仅在慢-5频段出现异常增高。pSS患者左辅助运动区dALFF表现出异常活动。此外,ALFF慢5频段识别的脑区差异与某些神经心理学量表相关。结论:本研究表明,ALFF指标可以更好地了解pSS患者区域脑功能的变化,这些变化具有频率依赖性和时间变异性特征,补充了传统的指标,增强了我们对pSS脑功能的理解,并表明ALFF可能成为探索pSS患者潜在神经机制的新工具。
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来源期刊
Lupus Science & Medicine
Lupus Science & Medicine RHEUMATOLOGY-
CiteScore
5.30
自引率
7.70%
发文量
88
审稿时长
15 weeks
期刊介绍: Lupus Science & Medicine is a global, peer reviewed, open access online journal that provides a central point for publication of basic, clinical, translational, and epidemiological studies of all aspects of lupus and related diseases. It is the first lupus-specific open access journal in the world and was developed in response to the need for a barrier-free forum for publication of groundbreaking studies in lupus. The journal publishes research on lupus from fields including, but not limited to: rheumatology, dermatology, nephrology, immunology, pediatrics, cardiology, hepatology, pulmonology, obstetrics and gynecology, and psychiatry.
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