Reduced phase angle as a potential indicator of mild cognitive impairment.

IF 1.7 4区医学 Q3 NUTRITION & DIETETICS

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-09-01 Epub Date: 2025-05-22 DOI:10.3164/jcbn.25-70

Mika Hasegawa, Hidenori Onishi, Yasutaka Mizukami, Yuki Niida, Tomoko Okamoto, Masafumi Kubota, Yuya Nakajima, Taisei Inoue, Hirohiko Ohama, Tokuharu Tanaka, Shinya Sugawara, Fumie Maeda, Akemi Koujimoto, Yuta Shimoura, Osamu Muto, Naohiro Konoshita, Akiko Matsunaga, Masamichi Ikawa, Hiroyuki Hayashi, Osamu Yamamura

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Abstract

In this study, we investigated the relationship between phase angle (PhA), measured using bioelectrical impedance analysis (BIA), and mild cognitive impairment (MCI). A cross-sectional analysis was conducted on 290 community residents (83.7% female, average age 74.9 years). Cognitive function was assessed using the Japanese version of the Montreal Cognitive Assessment (MoCA-J), with MCI defined as a score of ≤25. Body composition, including PhA, was measured using BIA. Multiple regression analysis was used to examine the association between PhA and MCI presence, adjusting for potential confounders. MCI was found in 168 participants. The PhA (leg) was significantly lower in those with MCI than in those without (p = 0.013). A significant association between leg PhA and MCI was identified in the regression model (β = 0.103, p = 0.015), with an adjusted R ² value of 0.50. These findings suggested that PhA may serve as an indicator of MCI. Longitudinal and intervention studies are needed to explore the potential of PhA in dementia prevention strategies. In addition, future research should focus on developing dementia prevention strategies that utilize PhA through longitudinal and interventional studies.

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相角减小作为轻度认知障碍的潜在指标。

在这项研究中，我们研究了用生物电阻抗分析（BIA）测量的相位角（PhA）与轻度认知障碍（MCI）之间的关系。对290名社区居民进行横断面分析，其中女性83.7%，平均年龄74.9岁。认知功能评估采用日文版蒙特利尔认知评估（MoCA-J）， MCI定义为≤25分。用BIA测定体成分，包括PhA。多元回归分析用于检查PhA和MCI存在之间的关系，调整潜在的混杂因素。168名参与者发现轻度认知障碍。MCI患者的PhA（腿部）明显低于无MCI患者（p = 0.013）。在回归模型中，腿部PhA与MCI之间存在显著相关性（β = 0.103, p = 0.015），调整后的r2值为0.50。这些发现提示PhA可能是MCI的一个指标。需要纵向和干预研究来探索PhA在痴呆预防策略中的潜力。此外，未来的研究应侧重于通过纵向和介入性研究开发利用PhA的痴呆预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Biochemistry and Nutrition 医学-营养学

CiteScore

4.30

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Clinical Biochemistry and Nutrition (JCBN) is an international, interdisciplinary publication encompassing chemical, biochemical, physiological, pathological, toxicological and medical approaches to research on lipid peroxidation, free radicals, oxidative stress and nutrition. The Journal welcomes original contributions dealing with all aspects of clinical biochemistry and clinical nutrition including both in vitro and in vivo studies.