Correlation between ultrasonographic features and molecular markers of cancer cell proliferation, invasion, and apoptosis in young patients with advanced breast cancer

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-09-17 DOI:10.1111/jog.70073

Hongmei Zhang, Lili Hu, Ping Li, Ge Sun

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引用次数: 0

Abstract

Objective

This study aimed to investigate the correlation between ultrasonographic features and the expression of genes (as molecular markers) related to cancer cell proliferation, invasion, and apoptosis in young patients with advanced breast cancer.

Methods

A total of 203 young patients with advanced breast cancer admitted to our hospital were enrolled and divided into a deceased group (n = 52) and a survival group (n = 151) based on overall survival status. Ultrasonographic features and expression levels of proliferation- (PKM2, Notch1), invasion-(Gab2, NUAK1), and apoptosis-related (Bcl-2) genes were compared between groups. The correlation between the Ki67 proliferation index and ultrasonographic features was also analyzed.

Results

Significant differences between the deceased and survival groups were identified in internal echogenicity, margin, morphology, blood flow grade, BI-RADS classification, and calcification (p <0.05). The deceased group exhibited significantly higher expression levels of PKM2, Notch1, Gab2, NUAK1, and Bcl-2 (p <0.05). Spearman analysis revealed significant positive correlations between adverse ultrasonographic features and the expression of PKM2, Notch1, Gab2, NUAK1, and Bcl-2 (p <0.01). Furthermore, Ki67 expression levels were significantly positively correlated with adverse features such as irregular margins, irregular morphology, and higher blood flow grade (p <0.01).

Conclusion

Proliferation-related genes (PKM2, Notch1), invasion-related genes (Gab2, NUAK1), the apoptosis-related gene Bcl-2, and the proliferation marker Ki67 are positively correlated with specific ultrasonographic features in young patients with advanced breast cancer, suggesting a link between imaging phenotypes and molecular markers of aggressiveness.

Abstract Image

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年轻晚期乳腺癌患者超声特征与肿瘤细胞增殖、侵袭及凋亡分子标志物的关系

目的：探讨年轻晚期乳腺癌患者超声声像图特征与肿瘤细胞增殖、侵袭、凋亡相关基因（作为分子标记）表达的相关性。方法：选取我院住院的年轻晚期乳腺癌患者203例，根据总生存状态分为死亡组（n = 52）和生存组（n = 151）。比较两组间增殖-（PKM2、Notch1）、侵袭-（Gab2、NUAK1）、凋亡相关基因（Bcl-2）的超声特征及表达水平。并分析了Ki67增殖指数与超声特征的相关性。结果：死亡组和生存组在内部回声、边缘、形态学、血流等级、BI-RADS分类和钙化方面存在显著差异(p)。增殖相关基因（PKM2、Notch1）、侵袭相关基因（Gab2、NUAK1）、凋亡相关基因Bcl-2、增殖标志物Ki67与年轻晚期乳腺癌患者的特定超声特征呈正相关，提示影像学表型与侵袭性分子标志物之间存在联系。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.