Obesity is an independent poor prognostic factor in lupus nephritis.

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2025-10-01 Epub Date: 2025-09-17 DOI:10.1177/09612033251375856
Francy Cuervo, Antoine Enfrein, Hans-Joachim Anders, Frederic A Houssiau, Farah Tamirou
{"title":"Obesity is an independent poor prognostic factor in lupus nephritis.","authors":"Francy Cuervo, Antoine Enfrein, Hans-Joachim Anders, Frederic A Houssiau, Farah Tamirou","doi":"10.1177/09612033251375856","DOIUrl":null,"url":null,"abstract":"<p><p>ObjectiveTo investigate whether obesity is a risk factor for chronic kidney disease G3 (CKD G3; eGFR <60 mL/min/1.73 m<sup>2</sup>) in lupus nephritis (LN).MethodsWe retrospectively reviewed 132 cases of biopsy-proven class III, IV or V incident LN for which quarterly data were available during a long follow-up period (median 140 months). Rates of complete renal remission, renal flare and CKD G3 were compared between obese (body mass index ≥30 kg/m<sup>2</sup>) and non-obese patients. Complete renal remission was defined as a urine protein to creatinine ratio (uPCR) < 0.5 g/g and a serum creatinine value <120 % of baseline. Renal flare was defined as the reappearance of an uPCR >1 g/g, leading to a repeat kidney biopsy and/or treatment change.ResultsBaseline characteristics of obese patients did not differ from non-obese patients. By contrast, time to CKD G3 and time to renal flare were statistically shorter in obese patients. Obesity significantly increased long-term risk for the progression of CKD [HR = 2.72 (CI95% 1.11-6.64), <i>p</i> = .028]. In a multivariate analysis, obesity was an independent risk factor for CKD G3 (<i>p</i> = .029).ConclusionA BMI ≥30 kg/m<sup>2</sup> is an independent poor prognostic factor for the progression of CKD in LN. More attention should therefore be paid to weight control in LN patients.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1292-1297"},"PeriodicalIF":1.9000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lupus","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/09612033251375856","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/17 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

ObjectiveTo investigate whether obesity is a risk factor for chronic kidney disease G3 (CKD G3; eGFR <60 mL/min/1.73 m2) in lupus nephritis (LN).MethodsWe retrospectively reviewed 132 cases of biopsy-proven class III, IV or V incident LN for which quarterly data were available during a long follow-up period (median 140 months). Rates of complete renal remission, renal flare and CKD G3 were compared between obese (body mass index ≥30 kg/m2) and non-obese patients. Complete renal remission was defined as a urine protein to creatinine ratio (uPCR) < 0.5 g/g and a serum creatinine value <120 % of baseline. Renal flare was defined as the reappearance of an uPCR >1 g/g, leading to a repeat kidney biopsy and/or treatment change.ResultsBaseline characteristics of obese patients did not differ from non-obese patients. By contrast, time to CKD G3 and time to renal flare were statistically shorter in obese patients. Obesity significantly increased long-term risk for the progression of CKD [HR = 2.72 (CI95% 1.11-6.64), p = .028]. In a multivariate analysis, obesity was an independent risk factor for CKD G3 (p = .029).ConclusionA BMI ≥30 kg/m2 is an independent poor prognostic factor for the progression of CKD in LN. More attention should therefore be paid to weight control in LN patients.

肥胖是影响狼疮性肾炎预后的独立因素。
目的探讨肥胖是否为狼疮肾炎(LN)患者慢性肾脏疾病G3 (CKD G3; eGFR 2)的危险因素。方法回顾性分析了132例经活检证实的III、IV或V级事件性LN病例,这些病例在较长的随访期间(中位140个月)可获得季度数据。比较肥胖(体重指数≥30 kg/m2)和非肥胖患者的肾脏完全缓解率、肾脏耀斑率和CKD G3。肾脏完全缓解定义为尿蛋白/肌酐比值(uPCR) < 0.5 g/g,血清肌酐值1 g/g,导致重复肾活检和/或治疗改变。结果肥胖患者的基线特征与非肥胖患者无差异。相比之下,肥胖患者到CKD G3和肾脏耀斑的时间在统计学上更短。肥胖显著增加CKD进展的长期风险[HR = 2.72 (CI95% 1.11-6.64), p = 0.028]。在多变量分析中,肥胖是CKD G3的独立危险因素(p = 0.029)。结论BMI≥30 kg/m2是LN患者CKD进展的独立不良预后因素。因此,LN患者应更加重视体重控制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信