ANKK1 Taq1A Gene Variance and Executive Functions in Female Youth with Binge Eating Disorder: A Cross-sectional Study.

IF 2 Q3 PSYCHIATRY
Ola M Ibrahim, Azza El-Bakry, Heba Baz, Mohamed A Khalil, Gihan Fouad Ahmad, Doaa R Ayoub, Shirin M El-Makawi
{"title":"ANKK1 Taq1A Gene Variance and Executive Functions in Female Youth with Binge Eating Disorder: A Cross-sectional Study.","authors":"Ola M Ibrahim, Azza El-Bakry, Heba Baz, Mohamed A Khalil, Gihan Fouad Ahmad, Doaa R Ayoub, Shirin M El-Makawi","doi":"10.1177/02537176251365051","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Binge eating disorder (BED) biological and psychological etiology is still not fully understood. This study investigates the relationship between the ANKK1 Taq1A gene variant and BED in female youth with obesity, while also assessing executive functions (EFs).</p><p><strong>Methods: </strong>The study included eighty young females with obesity, divided into BED and non-BED groups. EFs were assessed using the Stroop test, Digit Span, and the PEBL battery (including Card Sorting, Iowa Gambling, and Go/No-go tests). The ANKK1 Taq1A gene variance was detected via real-time PCR.</p><p><strong>Results: </strong>No significant differences were found in ANKK1 Taq1A genotypes or allele frequencies between the groups. However, the BED group exhibited worse cognitive flexibility, decision-making, and higher depression levels. Specifically, the BED group scored poorly on tests such as Card Sorting, Iowa Gambling, and Digit Span (<i>p</i> < .001, <i>p</i> = .005, <i>p</i> = 0.07, respectively). A logistic regression analysis indicated that worse cognitive flexibility and high depression severity significantly increased the probability of BED (<i>p</i> = .01, OR = 1.42; <i>p</i> = .001, OR = 1.26, respectively).</p><p><strong>Conclusions: </strong>No association was found between ANKK1 Taq1A gene variance and BED or EFs performance. The female youth with obesity and BED demonstrated worse cognitive flexibility and decision-making, along with greater depression severity. Worse cognitive flexibility and greater depression severity were found to increase the probability of BED. Thus, evaluating and addressing EF deficits in BED patients, along with managing co-morbid psychiatric conditions, is crucial for improving treatment outcomes.</p>","PeriodicalId":13476,"journal":{"name":"Indian Journal of Psychological Medicine","volume":" ","pages":"02537176251365051"},"PeriodicalIF":2.0000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436327/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Psychological Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/02537176251365051","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Binge eating disorder (BED) biological and psychological etiology is still not fully understood. This study investigates the relationship between the ANKK1 Taq1A gene variant and BED in female youth with obesity, while also assessing executive functions (EFs).

Methods: The study included eighty young females with obesity, divided into BED and non-BED groups. EFs were assessed using the Stroop test, Digit Span, and the PEBL battery (including Card Sorting, Iowa Gambling, and Go/No-go tests). The ANKK1 Taq1A gene variance was detected via real-time PCR.

Results: No significant differences were found in ANKK1 Taq1A genotypes or allele frequencies between the groups. However, the BED group exhibited worse cognitive flexibility, decision-making, and higher depression levels. Specifically, the BED group scored poorly on tests such as Card Sorting, Iowa Gambling, and Digit Span (p < .001, p = .005, p = 0.07, respectively). A logistic regression analysis indicated that worse cognitive flexibility and high depression severity significantly increased the probability of BED (p = .01, OR = 1.42; p = .001, OR = 1.26, respectively).

Conclusions: No association was found between ANKK1 Taq1A gene variance and BED or EFs performance. The female youth with obesity and BED demonstrated worse cognitive flexibility and decision-making, along with greater depression severity. Worse cognitive flexibility and greater depression severity were found to increase the probability of BED. Thus, evaluating and addressing EF deficits in BED patients, along with managing co-morbid psychiatric conditions, is crucial for improving treatment outcomes.

ANKK1 Taq1A基因变异和暴饮暴食症女性青年的执行功能:一项横断面研究
背景:暴食症(BED)的生物学和心理学病因尚不完全清楚。本研究探讨了ANKK1 Taq1A基因变异与女性肥胖青年BED之间的关系,同时也评估了执行功能(EFs)。方法:将80例肥胖的年轻女性分为BED组和非BED组。使用Stroop测试、数字跨度和PEBL测试(包括卡片分类、爱荷华赌博和Go/No-go测试)评估ef。实时荧光定量PCR检测ANKK1 Taq1A基因变异。结果:各组间ANKK1 Taq1A基因型及等位基因频率无显著差异。然而,BED组表现出更差的认知灵活性、决策能力和更高的抑郁水平。具体来说,BED组在卡片分类、爱荷华赌博和数字跨度等测试中得分很低(p < 0.001, p = 0.005, p = 0.07)。logistic回归分析显示,认知灵活性差和抑郁严重程度高显著增加BED的发生概率(p = 0.01, OR = 1.42; p = 0.001, OR = 1.26)。结论:ANKK1 Taq1A基因变异与BED或EFs表现无相关性。患有肥胖和BED的女性青年表现出更差的认知灵活性和决策能力,以及更严重的抑郁程度。更差的认知灵活性和更严重的抑郁程度会增加BED的可能性。因此,评估和解决BED患者的EF缺陷,以及管理共病精神疾病,对于改善治疗效果至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
4.80
自引率
7.10%
发文量
116
审稿时长
12 weeks
期刊介绍: The Indian Journal of Psychological Medicine (ISSN 0253-7176) was started in 1978 as the official publication of the Indian Psychiatric Society South Zonal Branch. The journal allows free access (Open Access) and is published Bimonthly. The Journal includes but is not limited to review articles, original research, opinions, and letters. The Editor and publisher accept no legal responsibility for any opinions, omissions or errors by the authors, nor do they approve of any product advertised within the journal.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信