Ola M Ibrahim, Azza El-Bakry, Heba Baz, Mohamed A Khalil, Gihan Fouad Ahmad, Doaa R Ayoub, Shirin M El-Makawi
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引用次数: 0
Abstract
Background: Binge eating disorder (BED) biological and psychological etiology is still not fully understood. This study investigates the relationship between the ANKK1 Taq1A gene variant and BED in female youth with obesity, while also assessing executive functions (EFs).
Methods: The study included eighty young females with obesity, divided into BED and non-BED groups. EFs were assessed using the Stroop test, Digit Span, and the PEBL battery (including Card Sorting, Iowa Gambling, and Go/No-go tests). The ANKK1 Taq1A gene variance was detected via real-time PCR.
Results: No significant differences were found in ANKK1 Taq1A genotypes or allele frequencies between the groups. However, the BED group exhibited worse cognitive flexibility, decision-making, and higher depression levels. Specifically, the BED group scored poorly on tests such as Card Sorting, Iowa Gambling, and Digit Span (p < .001, p = .005, p = 0.07, respectively). A logistic regression analysis indicated that worse cognitive flexibility and high depression severity significantly increased the probability of BED (p = .01, OR = 1.42; p = .001, OR = 1.26, respectively).
Conclusions: No association was found between ANKK1 Taq1A gene variance and BED or EFs performance. The female youth with obesity and BED demonstrated worse cognitive flexibility and decision-making, along with greater depression severity. Worse cognitive flexibility and greater depression severity were found to increase the probability of BED. Thus, evaluating and addressing EF deficits in BED patients, along with managing co-morbid psychiatric conditions, is crucial for improving treatment outcomes.
背景:暴食症(BED)的生物学和心理学病因尚不完全清楚。本研究探讨了ANKK1 Taq1A基因变异与女性肥胖青年BED之间的关系,同时也评估了执行功能(EFs)。方法:将80例肥胖的年轻女性分为BED组和非BED组。使用Stroop测试、数字跨度和PEBL测试(包括卡片分类、爱荷华赌博和Go/No-go测试)评估ef。实时荧光定量PCR检测ANKK1 Taq1A基因变异。结果:各组间ANKK1 Taq1A基因型及等位基因频率无显著差异。然而,BED组表现出更差的认知灵活性、决策能力和更高的抑郁水平。具体来说,BED组在卡片分类、爱荷华赌博和数字跨度等测试中得分很低(p < 0.001, p = 0.005, p = 0.07)。logistic回归分析显示,认知灵活性差和抑郁严重程度高显著增加BED的发生概率(p = 0.01, OR = 1.42; p = 0.001, OR = 1.26)。结论:ANKK1 Taq1A基因变异与BED或EFs表现无相关性。患有肥胖和BED的女性青年表现出更差的认知灵活性和决策能力,以及更严重的抑郁程度。更差的认知灵活性和更严重的抑郁程度会增加BED的可能性。因此,评估和解决BED患者的EF缺陷,以及管理共病精神疾病,对于改善治疗效果至关重要。
期刊介绍:
The Indian Journal of Psychological Medicine (ISSN 0253-7176) was started in 1978 as the official publication of the Indian Psychiatric Society South Zonal Branch. The journal allows free access (Open Access) and is published Bimonthly. The Journal includes but is not limited to review articles, original research, opinions, and letters. The Editor and publisher accept no legal responsibility for any opinions, omissions or errors by the authors, nor do they approve of any product advertised within the journal.