Ketogenic diet in neonates: effects, pitfalls, and a paradigm from a preterm newborn affected by pyruvate dehydrogenase deficiency.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-09-17 DOI:10.1038/s41372-025-02427-6

Sokratis Katsoudas, Luis A Umana, Rebekah Clarke, Jennifer Thomas, Michelle Machie, Dimitrios Angelis

引用次数: 0

Abstract

The application of ketogenic diet (KD) in newborns is rare and mainly reserved for specific metabolic and seizure disorders. Furthermore, only case reports describe the effects of KD in premature infants. Here, we summarize the recent advances, indications, mechanisms of action and practical issues related to KD. We also provide a paradigm of a preterm male infant born at 34 weeks with pyruvate dehydrogenase deficiency, highlighting the therapeutic challenges and outcomes with the KD. This report underscores the complexities of managing metabolic disorders in neonates and the effects of KD.

查看原文本刊更多论文

生酮饮食对新生儿的影响：丙酮酸脱氢酶缺乏症对早产新生儿的影响、缺陷和范例。

生酮饮食（KD）在新生儿中的应用是罕见的，主要用于特定的代谢和癫痫性疾病。此外，只有病例报告描述了KD对早产儿的影响。在这里，我们总结了KD的最新进展、适应症、作用机制和实际问题。我们还提供了一个34周出生的丙酮酸脱氢酶缺乏症早产男婴的范例，强调了KD的治疗挑战和结果。本报告强调了管理新生儿代谢紊乱的复杂性和KD的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.