Bentall Versus David Procedure for Aortic Root Replacement in Patients With Bicuspid Aortic Valve: Systematic Review and Meta-Analysis Using Reconstructed Time-to-Event Data.
Ioannis Zoupas, Andreas Sarantopoulos, Nikolaos Schizas, Evangelos Boultadakis, Ioannis Koukis, Ibrahim Manna, Dimitrios C Iliopoulos
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引用次数: 0
Abstract
Background: There is little evidence comparing the effectiveness of valve-sparing aortic root replacement with the David procedure and replacement with a composite graft (Bentall procedure) for patients with bicuspid aortic valves (BAV). This systematic review and meta-analysis compared the overall survival and the freedom from re-intervention in BAV patients who underwent root replacement with either the David or Bentall procedure.
Methods: Two databases were searched for studies including BAV patients who underwent either the David or Bentall operation. This review was performed in accordance with the recommendations of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) statement. One-stage and two-stage meta-analyses were conducted with Kaplan-Meier-derived individual patient data and a random-effects model.
Results: Thirteen studies were included, providing data about 1,264 BAV patients who underwent a Bentall procedure and 602 patients who underwent a David procedure. During a follow-up period of 8 years, overall survival rates were significantly improved in the David group compared with the Bentall group (hazard ratio [HR] 0.19, 95% confidence interval [CI] 0.08-0.42; p<0.001). This was confirmed by the two-stage meta-analysis (HR 0.22, 95% CI 0.09-0.55; p=0.00, I2=0.00%). Regarding freedom from re-intervention, splitting timepoint analysis revealed that no arm offered a statistically significant advantage (HR 1.24, 95% CI 0.58-2.63; p=0.575). Finally, the David operation was associated with fewer postoperative complications.
Conclusions: The David operation is associated with improved survival and lower complication rates than the Bentall procedure for patients with BAV. However, freedom from re-operation rates were comparable between the two procedures.
期刊介绍：
Heart, Lung and Circulation publishes articles integrating clinical and research activities in the fields of basic cardiovascular science, clinical cardiology and cardiac surgery, with a focus on emerging issues in cardiovascular disease. The journal promotes multidisciplinary dialogue between cardiologists, cardiothoracic surgeons, cardio-pulmonary physicians and cardiovascular scientists.
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