Comparison of biomarkers and laboratory results in unaffected, moderate, and severe COVID-19 recovered patients.

Abstract

Aim: To compare several laboratory results, including liver function, lipid metabolism (HDL), pulmonary function, and hematological parameters among COVID-19 recovered patients who were divided into two groups (asymptomatic/mild vs. moderate/severe).

Method: The sample consisted of patients matched by age and gender. These patients were divided into two groups. The first group consisted of mild or mild cases, and the second group included moderate and severe cases, classified based on their need for oxygen. Blood samples were collected from all participants, and analyses for complete blood count, liver function markers, kidney function markers, and lipid profiles were conducted at the Health Center of Jordan University of Science and Technology and King Abdullah University laboratories.

Results: The analysis revealed Significant differences were noted in ALT (p = 0.002), DBC (p = 0.005), HDL (p = 0.035), Notably, the Forced Vital Capacity (FVC) showed a significant difference (F = 6.292, p = 0.012). The FEV1/FVC ratio was also highly significant (F = 45.054, p = 0.000).

Conclusion: In this descriptive cohort study, the results indicating that specific biomarkers, such as elevated WBC and liver enzymes, are significantly associated with severe post-COVID outcomes. These findings highlight the systemic impact of the disease in severe cases, affecting multiple or one organ.