Trends in Benzisothiazolinone Sensitization: A Retrospective Analysis From 2010 to 2022, in a Tertiary Belgian Hospital.

IF 4.6 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2025-09-17 DOI:10.1111/cod.70017

Anne Herman, Kiswendsida Sawadogo, Marie Baeck

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引用次数: 0

Abstract

Background: Benzisothiazolinone is a preservative responsible for allergic contact dermatitis, with occupational exposure being a common source of sensitisation.

Objectives: To investigate the prevalence of positive patch test reactions to benzisothiazolinone (BIT) in Belgium, between January 2010 and December 2022, and to assess co-sensitisations to other isothiazolinone derivatives in sensitised patients.

Methods: A retrospective monocentric study of patch test results with benzisothiazolinone (BIT) 0.1% petrolatum observed in patients attending a Belgian tertiary hospital. Prevalence, demographic data, concomitant patch test reactions, and clinical relevance were analysed.

Results: Overall, 65 of 6128 patients (1.06%) had a positive patch test reaction to benzisothiazolinone, and its sensitisation rate increased from 0.39% in 2010 to 3.72% in 2019 (followed by a decline to 0.71% in 2022). Occupational exposure was relevant in 20% of cases, with painters and metalworkers being the most affected professions. Unexpectedly, 10.8% of BIT-sensitised patients underwent patch testing due to complications following orthopaedic prosthesis implantation.

Conclusions: This study confirms a significant rise in BIT sensitisation over time, followed by a recent unexplained decline. Occupational exposure remains a major risk factor, but other environmental sources, including consumer products, such as leather products, should not be overlooked. The BIT sensitisation in orthopaedic prosthesis-related complications requires further investigation.

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2010 - 2022年比利时某三级医院苯并异噻唑啉酮致敏趋势回顾性分析

背景：苯并噻唑啉酮是过敏性接触性皮炎的防腐剂，职业暴露是致敏的常见来源。目的：调查2010年1月至2022年12月期间比利时对苯并异噻唑啉酮（BIT）的膜片试验阳性反应的发生率，并评估过敏患者对其他异噻唑啉酮衍生物的共致敏性。方法：回顾性单中心研究在比利时一家三级医院就诊的患者使用0.1%苯并异噻唑啉酮（BIT）凡士林进行斑贴试验的结果。分析了患病率、人口统计数据、伴随的斑贴试验反应和临床相关性。结果：总体而言，6128例患者中有65例（1.06%）对苯并异噻唑啉酮有斑贴试验阳性反应，其致敏率从2010年的0.39%上升至2019年的3.72%（2022年下降至0.71%）。20%的病例与职业暴露有关，油漆工和金属工人是受影响最大的职业。出乎意料的是，10.8%的bit敏感患者由于矫形假体植入后的并发症而进行了贴片测试。结论：该研究证实，随着时间的推移，BIT敏感性显著上升，随后出现了近期不明原因的下降。职业接触仍然是一个主要的风险因素，但其他环境来源，包括消费品，如皮革制品，也不应忽视。BIT在骨科假体相关并发症中的致敏作用有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".