Predictive Analysis of Coagulation Dysfunction in Elderly Patients Caused by Cefoperazone Sodium-Sulbactam Sodium Use.

Abstract

Objective: To retrospectively analyze the influencing factors of coagulation dysfunction caused by intravenous infusion of cefoperazone-sulbactam in elderly patients, and to provide a safety reference for the clinical selection of treatment.

Methods: A total of 113 patients aged ≥60 years who were hospitalized in different departments of Qinghai Red Cross Hospital from January 2020 to November 2022 and treated with cefoperazone-sulbactam were selected as the research objects. From multiple aspects such as the patients' gender, ethnicity, medication time, liver and kidney function, blood cell analysis, procalcitonin, and coagulation function, logistic regression analysis combined with receiver operating characteristic (ROC) curve analysis were used to analyze the influencing factors of coagulation disorders caused by cefoperazone-sulbactam in elderly patients.

Results: Among the 113 patients treated with cefoperazone sodium-sulbactam sodium, 49 cases (43.4%) had coagulation disorders. Logistic regression analysis showed that age, platelet count, and creatinine level of the patients were the influencing factors of coagulation disorders caused by cefoperazone-sulbactam (P<0.05). The older the age and the lower the platelet count and the higher the creatinine level, the greater the risk of coagulation disorders in patients. The area under the ROC curve of the combined predictor was 0.820 (P<0.05), which was better than other single factors.

Conclusion: When elderly patients are older, with lower platelet counts and higher creatinine levels, the diagnostic efficacy of combining the above indicators is better than that of a single indicator. Therefore, detecting the levels of the above indicators is helpful for the diagnosis and disease evaluation of coagulation dysfunction caused by cefoperazone sodium-sulbactam sodium.