Letting Go of Pains and Other Dogmas

IF 3.4 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2025-09-18 DOI:10.1002/cmdc.202500199

Christina L. L. Chai

引用次数: 0

Abstract

Drug discovery and development is a complex, arduous and uncertain activity that is more likely to fail than succeed. To improve the odds of success, numerous dogmas have become entrenched in medicinal chemistry. This has unwittingly led to stifling of creativity and innovation, rather than improve the practice of medicinal chemistry. It is time to let go of these dogmas and embrace an open mindset for discovery and knowledge creation.

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放下痛苦和其他教条。

药物发现和开发是一项复杂、艰巨和不确定的活动，失败的可能性大于成功的可能性。为了提高成功的几率，许多教条已经在药物化学中根深蒂固。这在不知不觉中导致了创造力和创新的扼杀，而不是改善药物化学的实践。是时候放弃这些教条，以开放的心态去发现和创造知识了。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.