Disrupted Brain Structure–Function Coupling and Its Mediating Effects on the Associations Between Cerebral Small Vessel Disease Burden and Cognitive Dysfunction

IF 5 1区医学 Q1 NEUROSCIENCES

CNS Neuroscience & Therapeutics Pub Date : 2025-09-18 DOI:10.1111/cns.70604

Na Wang, Lingfei Guo, Yian Gao, Chaofan Sui, Xinyue Zhang, Yuanyuan Wang, Yajie Fu, Nan Zhang, Yena Che, Hongwei Wen, Changhu Liang

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Abstract

Aims

We aimed to specify relationships among cerebral small vessel disease (CSVD) burden, cognitive dysfunction, and brain structure–function coupling changes.

Methods

A total of 108 patients with mild CSVD burden (CSVD-m), 53 patients with severe CSVD burden (CSVD-s), and 76 healthy controls (HC) were included in this study. The ratio of regional homogeneity (ReHo) or amplitude of low-frequency fluctuation (ALFF) to gray matter volume (GMV) was calculated as an indicator of voxel-wise structure–function coupling.

Results

Significantly decreased or increased ReHo–GMV and ALFF–GMV coupling values in patients with severe CSVD burden were primarily found in several brain regions, and the disrupted structure–function coupling in the right putamen mediated the relationship between CSVD burden and cognitive dysfunction.

Conclusions

Brain structure–function coupling characterized by ReHo–GMV and ALFF–GMV mediated the cognitive dysfunction caused by CSVD and was an innovative and effective brain imaging indicator for exploring the association between CSVD burden and cognitive dysfunction.

Abstract Image

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脑结构-功能耦合中断及其在脑血管疾病负担与认知功能障碍之间的中介作用

目的：我们旨在明确脑小血管疾病（CSVD）负担、认知功能障碍和脑结构-功能耦合变化之间的关系。方法：选取108例轻度CSVD负担（CSVD-m）患者、53例重度CSVD负担（CSVD-s）患者和76例健康对照（HC）进行研究。计算区域均匀性（ReHo）或低频波动幅度（ALFF）与灰质体积（GMV）的比值，作为体素方向结构-功能耦合的指标。结果：重度CSVD负担患者的ReHo-GMV和ALFF-GMV偶联值主要在多个脑区显著降低或升高，右侧壳核结构-功能偶联的破坏介导了CSVD负担与认知功能障碍的关系。结论：以ReHo-GMV和ALFF-GMV为特征的脑结构-功能耦合介导了CSVD引起的认知功能障碍，是探索CSVD负担与认知功能障碍关系的创新有效的脑成像指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.