Objective physical activity and Alzheimer's disease burden in the population-based Rotterdam Study

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-09-18 DOI:10.1002/alz.70655

Phuong Thuy Nguyen Ho, Meike W. Vernooij, Trudy Voortman, María Rodriguez-Ayllon, Julia Neitzel

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Abstract

INTRODUCTION

Physical activity is linked to lower dementia risk, but its connection to Alzheimer's disease (AD) pathology remains uncertain. This study examined the relationship between objectively measured physical activity and early AD biomarkers in cognitively unimpaired adults.

METHODS

Accelerometer-measured physical activity and plasma AD biomarkers (beta-amyloid [Aβ]42/Aβ40, p-tau217) were assessed in 242 participants (age = 63.37 [54–79] years) of the population-based Rotterdam Study. Cortical Aβ was assessed via ¹⁸F-florbetaben positron emission tomography (PET) 7 years later. Robust regression assessed the relationship between physical activity, plasma AD biomarkers, and Aβ PET burden, while compositional analysis examined how the time-use composition relates to AD outcomes.

RESULTS

Physical activity was not associated with plasma Aβ42/Aβ40, p-tau217, or brain Aβ burden 7 years later. Reallocating awake sedentary time to physical activity showed no association with AD biomarkers.

DISCUSSION

No relationship was identified between physical activity and AD biomarkers, suggesting physical activity might affect dementia risk through other pathways or in an earlier life phase.

Highlights

Physical activity was not associated with plasma beta-amyloid (Aβ)42/Aβ40 nor p-tau217.
No association was observed between physical activity and brain Aβ 7 years later.
Age, sex, and apolipoprotein E ε4 carriership did not moderate these relationships.
Reallocating 30 minutes of sedentary time to physical activity resulted in no change in Alzheimer's disease (AD) biomarkers.

Abstract Image

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目的：以人群为基础的鹿特丹研究中体力活动与阿尔茨海默病负担的关系。

体育活动与较低的痴呆风险有关，但其与阿尔茨海默病（AD）病理的关系仍不确定。本研究考察了在认知未受损的成年人中客观测量的身体活动与早期AD生物标志物之间的关系。方法：在以人群为基础的鹿特丹研究中，对242名参与者（年龄= 63.37[54-79]岁）进行了加速计测量的身体活动和血浆AD生物标志物（β -淀粉样蛋白[Aβ]42/Aβ40， p-tau217）的评估。7年后通过18F-florbetaben正电子发射断层扫描（PET）评估皮质Aβ。稳健回归评估了身体活动、血浆AD生物标志物和Aβ PET负担之间的关系，而成分分析研究了时间使用成分与AD结果的关系。结果：7年后，体力活动与血浆Aβ42/Aβ40、p-tau217或脑Aβ负荷无关。将清醒的久坐时间重新分配给体力活动与AD生物标志物没有关联。讨论：没有发现体育活动与AD生物标志物之间的关系，这表明体育活动可能通过其他途径或在生命早期阶段影响痴呆风险。重点：体力活动与血浆β -淀粉样蛋白（Aβ）42/Aβ40和p-tau217无关。7年后，没有观察到体育活动与大脑Aβ之间的关联。年龄、性别和载脂蛋白ε4携带者对这些关系没有调节作用。将30分钟的久坐时间重新分配给身体活动不会导致阿尔茨海默病（AD）生物标志物的变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.