Sustainable Strategies for Carbazole Synthesis: A Green Chemistry Perspective

IF 3.6 3区 医学 Q2 CHEMISTRY, MEDICINAL
Drashti Shah, Maitri Patel, Abha Vyas, Ashish Patel
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引用次数: 0

Abstract

Carbazoles are an important class of aromatic compounds having numerous applications in pharmaceuticals, including anticancer, anti-inflammatory, and antibacterial activity. Traditional synthesis methods, while successful, frequently use toxic chemicals, hazardous solvents, and energy-intensive procedures, raising serious environmental problems. This study discusses current advances in green carbazole synthetic approaches, with a focus on environmentally friendly strategies such as microwave-assisted reactions, photoredox catalysis, and the use of recyclable metal catalysts such as gold and palladium. Sustainable techniques, such as solvent-free processes, aqueous systems, and renewable resources, are explored alongside mechanistic insights into improving atom economy and reducing waste. These changes, which incorporate green chemistry concepts, not only increase the sustainability of carbazole synthesis but also expand its therapeutic potential, paving the way for environmentally friendly advances in medicinal chemistry.

Abstract Image

咔唑合成的可持续策略:绿色化学视角。
咔唑是一类重要的芳香族化合物,在药物中有许多应用,包括抗癌、抗炎和抗菌活性。传统的合成方法虽然成功,但经常使用有毒化学品、有害溶剂和能源密集型程序,引起严重的环境问题。本研究讨论了绿色咔唑合成方法的最新进展,重点介绍了环境友好型策略,如微波辅助反应、光氧化还原催化和使用可回收金属催化剂,如金和钯。可持续技术,如无溶剂工艺,水系统和可再生资源,与提高原子经济性和减少浪费的机械见解一起探索。这些变化结合了绿色化学概念,不仅增加了咔唑合成的可持续性,而且扩大了其治疗潜力,为药物化学的环保进步铺平了道路。
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来源期刊
Archiv der Pharmazie
Archiv der Pharmazie 医学-化学综合
CiteScore
7.90
自引率
5.90%
发文量
176
审稿时长
3.0 months
期刊介绍: Archiv der Pharmazie - Chemistry in Life Sciences is an international journal devoted to research and development in all fields of pharmaceutical and medicinal chemistry. Emphasis is put on papers combining synthetic organic chemistry, structural biology, molecular modelling, bioorganic chemistry, natural products chemistry, biochemistry or analytical methods with pharmaceutical or medicinal aspects such as biological activity. The focus of this journal is put on original research papers, but other scientifically valuable contributions (e.g. reviews, minireviews, highlights, symposia contributions, discussions, and essays) are also welcome.
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