Disruption to the gut microbiome by non-antibiotics is linked to infection risk

IF 7.2 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2025-09-18 DOI:10.1016/j.chembiol.2025.08.008

Caroline Tawk , Till Strowig

引用次数: 0

Abstract

Human-targeted drugs alter the composition and function of the gut microbiome, but their effect on the risk of gastrointestinal infection has received little attention. In two studies, Grieβhammer et al.¹ and Kumar et al.² identified non-antibiotic drugs that affect the microbiome’s natural defense against enteropathogen colonization and subsequent host infection.

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非抗生素对肠道微生物群的破坏与感染风险有关

人类靶向药物可以改变肠道微生物群的组成和功能，但它们对胃肠道感染风险的影响却很少受到关注。在两项研究中，Grieβhammer等人1和Kumar等人2发现非抗生素药物会影响微生物群对肠道病原菌定植和随后的宿主感染的天然防御。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.