Barcode-Integrated Cellulose Based Microfluidic System for Intelligent Point-of-Care Blood Typing

IF 5.4 2区 工程技术 Q1 BIOCHEMICAL RESEARCH METHODS
Lab on a Chip Pub Date : 2025-09-18 DOI:10.1039/d5lc00688k
Chunrui Chen, Tonghuan Zhan, Lin Hu, Mengyuan Ding, Xianchang Wu, Heng Wang, Bing Xu
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Abstract

Accurate and rapid blood typing plays a critical role in life-saving clinical procedures such as blood transfusions and organ transplantation. Herein, we proposed a novel blood typing system (BloodStrips) that combines cellulose based microfluidics with universal barcode technology, achieving intelligent, rapid, and user-friendly blood type detection. The BloodStrips system employed heat transfer printing to create barcode patterns on hydrophobic cotton substrates, and integrated cotton threads to construct hydrophilic channels. Meanwhile, the swinging elution method was harnessed to remove free red blood cells (RBCs) while retaining aggregated RBCs on the cotton threads, thereby resulting in creating a distinct white/red contrast at the macro level (white represents cotton thread, red represents bloodstain). The white/red barcodes with different combinations was used to represent various blood types. Based on this principle, we further developed a portable and automated blood tying chip called BloodBar chip. Noting that this device leverages simple and straightforward smartphone scanning technique to decipher blood types, avoiding reading errors caused by ambient light intensity and personal bias. This work provides a universal and intelligent visual diagnostic platform for simple, rapid, and accurate blood typing, which may find wide applications in developing countries or resource-limited areas.
基于纤维素的条形码集成微流体系统,用于智能护理点血型
准确和快速的血型在挽救生命的临床程序中发挥着关键作用,如输血和器官移植。在此,我们提出了一种新型的血型检测系统(BloodStrips),该系统结合了纤维素微流体和通用条形码技术,实现了智能、快速和用户友好的血型检测。BloodStrips系统采用热转印技术在疏水性棉基材上创建条形码图案,并集成棉线来构建亲水性通道。同时,摆动洗脱法被用来去除游离红细胞(rbc),同时保留棉线上聚集的红细胞,从而在宏观水平上产生明显的白/红对比(白色代表棉线,红色代表血迹)。使用不同组合的白/红条形码代表不同的血型。基于这一原理,我们进一步开发了一种便携式、自动化的血液捆绑芯片,称为BloodBar芯片。值得注意的是,该设备利用简单直接的智能手机扫描技术来破译血型,避免了由环境光强度和个人偏见引起的读取错误。这项工作为简单、快速和准确的血型诊断提供了一个通用的智能视觉诊断平台,在发展中国家或资源有限的地区可能会得到广泛应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Lab on a Chip
Lab on a Chip 工程技术-化学综合
CiteScore
11.10
自引率
8.20%
发文量
434
审稿时长
2.6 months
期刊介绍: Lab on a Chip is the premiere journal that publishes cutting-edge research in the field of miniaturization. By their very nature, microfluidic/nanofluidic/miniaturized systems are at the intersection of disciplines, spanning fundamental research to high-end application, which is reflected by the broad readership of the journal. Lab on a Chip publishes two types of papers on original research: full-length research papers and communications. Papers should demonstrate innovations, which can come from technical advancements or applications addressing pressing needs in globally important areas. The journal also publishes Comments, Reviews, and Perspectives.
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