Impact of Symptom Clusters on Fear of Progression in Kidney Transplant Recipients.

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Transplantation proceedings Pub Date : 2025-09-15 DOI:10.1016/j.transproceed.2025.07.029

Minghuan Zhong, Weiwei Cao, Jingjing Yang, Li Ma, Yulin Niu, Bei Ding

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Abstract

Objective: To investigate the association between symptom clusters and fear of progression (FoP) in kidney transplant recipients, and to provide evidence for clinical interventions.

Methods: A cross-sectional study was conducted using convenience sampling, enrolling 209 kidney transplant recipients from a tertiary hospital between September 2024 and January 2025. Participants were assessed using the Fear of Progression Questionnaire-Short Form (FoP-Q-SF) and the Modified Transplant Symptom Occurrence and Symptom Distress Scale (MTSOSD-62).

Results: The mean total FoP score was 25.15 ± 9.06. Exploratory factor analysis identified 5 symptom clusters, accounting for 72.3% of the total variance. The emotional-related symptom cluster had the highest prevalence (31/209), while patients with neurocognitive symptom clusters reported the highest FoP scores (31.5 ± 9.22). Spearman correlation analysis revealed that FoP was significantly and positively associated with the physical discomfort cluster (r = 0.194), the emotional-related cluster (r = 0.452), and the neurocognitive function cluster (r = 0.255) (P < .001). Multiple regression analysis confirmed that these 3 clusters explained 42.7% of the variance in FoP.

Conclusion: Symptom clusters are closely associated with FoP in kidney transplant recipients. Greater symptom severity is linked to higher levels of FoP. It is recommended that clinicians strengthen symptom cluster management and implement systematic interventions to reduce patients' FoP.

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肾移植受者症状群对进展恐惧的影响。

目的：探讨肾移植受者症状聚类与进展恐惧（FoP）的关系，为临床干预提供依据。方法：采用方便抽样的横断面研究方法，于2024年9月至2025年1月在某三级医院纳入209例肾移植受者。使用恐惧进展问卷-短表（top - q - sf）和改良移植症状发生和症状困扰量表（MTSOSD-62）对参与者进行评估。结果：平均总FoP评分为25.15±9.06分。探索性因子分析鉴定出5个症状类，占总方差的72.3%。情绪相关症状群的患病率最高（31/209），而神经认知症状群的FoP评分最高（31.5±9.22）。Spearman相关分析显示，FoP与身体不适类（r = 0.194）、情绪相关类（r = 0.452）和神经认知功能类（r = 0.255）呈显著正相关（P < 0.001）。多元回归分析证实，这3个聚类解释了42.7%的FoP方差。结论：肾移植受者的症状群与FoP密切相关。更严重的症状与更高水平的FoP有关。建议临床医生加强症状群管理，并实施系统干预，以减少患者的FoP。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Transplantation proceedings

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