Lauren Michiels, Mahrukh Shameem, Eliane Vanhoffelen, Agustin Reséndiz-Sharpe, Simon A Johnston, Nicolas Beziere, Greetje Vande Velde
{"title":"Fungal infections in focus: accelerating non-invasive imaging from preclinical insights to clinical breakthroughs.","authors":"Lauren Michiels, Mahrukh Shameem, Eliane Vanhoffelen, Agustin Reséndiz-Sharpe, Simon A Johnston, Nicolas Beziere, Greetje Vande Velde","doi":"10.1038/s44303-025-00105-y","DOIUrl":null,"url":null,"abstract":"<p><p>Invasive fungal diseases (IFDs) present a growing clinical challenge, underscoring the urgent need for improved diagnostics, therapeutics and mechanistic understanding. This review highlights the key role of innovative imaging techniques across all scales - ranging from whole-body-level diagnostics and therapy monitoring to host-pathogen interactions at cellular resolution in both clinical and preclinical settings. These imaging modalities facilitate translation of preclinical innovations into clinical applications, accelerating research and advancing IFD management.</p>","PeriodicalId":501709,"journal":{"name":"npj Imaging","volume":"3 1","pages":"42"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441154/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"npj Imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s44303-025-00105-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Invasive fungal diseases (IFDs) present a growing clinical challenge, underscoring the urgent need for improved diagnostics, therapeutics and mechanistic understanding. This review highlights the key role of innovative imaging techniques across all scales - ranging from whole-body-level diagnostics and therapy monitoring to host-pathogen interactions at cellular resolution in both clinical and preclinical settings. These imaging modalities facilitate translation of preclinical innovations into clinical applications, accelerating research and advancing IFD management.