Clinical Outcomes of Radiologically Node-Negative Oropharyngeal Squamous Cell Carcinoma: A Retrospective Analysis.

IF 2.2 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-09-17 DOI:10.1002/hed.70047

Mohamed Elmarghani, Panagiotis Asimakopoulos, Mathew Donachie, Rhona Hurley, Mohd Slim, Claire Paterson, Olha Zahranychna, Catriona Douglas

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引用次数: 0

Abstract

Background: Oropharyngeal squamous cell carcinoma (OPSCC) shows distinct clinical patterns based on HPV status. In the UK, rising HPV-positive cases have changed the disease's demographics and prognosis. While nodal involvement is a key prognostic factor, a subset presents with radiologically node-negative (N0) disease, where optimal management is unclear. This study examines survival outcomes in these patients, stratified by HPV status.

Methods: A retrospective analysis of 1001 OPSCC cases (2012-2020) identified 249 N0 patients. After excluding 39 with unknown HPV status, 210 cases (37% HPV-positive) were analyzed. Demographic, clinical, and treatment data were assessed, with survival analyzed using Kaplan-Meier curves.

Results: Overall survival was 56.2%, significantly higher in HPV-positive patients (75.3% vs. 45.1%, p < 0.001). HPV-negative patients had a smaller tumor size, were more often female, with higher smoking, alcohol use, and deprivation. Despite earlier T-stage, they had worse performance scores and received surgery or supportive care more often.

Discussion: HPV negative OPSCC retains poor prognosis even in node-negative OPSCC and smaller tumor size on presentation.

查看原文本刊更多论文

放射学淋巴结阴性口咽鳞状细胞癌的临床结果：回顾性分析。

背景：口咽鳞状细胞癌（OPSCC）表现出基于HPV状态的不同临床模式。在英国，hpv阳性病例的增加改变了该疾病的人口统计和预后。虽然淋巴结受累是一个关键的预后因素，但有一部分患者影像学上表现为淋巴结阴性（N0），其最佳治疗方法尚不清楚。本研究检查了这些患者的生存结果，按HPV状态分层。方法：回顾性分析2012-2020年1001例OPSCC患者249例。在排除39例未知HPV状态后，分析了210例（37% HPV阳性）。对人口统计学、临床和治疗数据进行评估，并使用Kaplan-Meier曲线分析生存率。结果：总生存率为56.2%，HPV阳性患者的生存率显著高于前者（75.3% vs. 45.1%）。讨论：HPV阴性的OPSCC即使在淋巴结阴性的OPSCC和较小的肿瘤出现时，预后也很差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.