A rare case of in situ follicular B-cell neoplasm involving sebaceous lymphadenoma.

IF 0.6 4区医学 Q4 HEMATOLOGY

Journal of Hematopathology Pub Date : 2025-09-17 DOI:10.1007/s12308-025-00657-3

Ejas Palathingal Bava, Wamidh L Alkhoory, Sharmila B Ghosh

引用次数: 0

Abstract

In situ follicular neoplasia (ISFN) is characterized by a monoclonal proliferation of BCL2-positive B cells harboring the translocation t(14;18)(q32;q21). These cells are confined to follicle centers and are usually identified incidentally, with a very low risk of progression to follicular lymphoma. Sebaceous lymphadenoma is a rare, benign salivary gland tumor, most commonly arising in the parotid gland, and is histologically defined by solid epithelial nests and cysts with sebaceous differentiation in a hyperplastic lymphoid stroma. We report an unusual case of ISFN arising within a sebaceous lymphadenoma. To the best of our knowledge, this association has not previously been reported.

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一例罕见的原位滤泡性b细胞肿瘤累及皮脂腺淋巴结瘤。

原位滤泡瘤（ISFN）的特点是bcl2阳性B细胞的单克隆增殖携带易位t(14;18)（q32;q21）。这些细胞局限于滤泡中心，通常是偶然发现的，发展为滤泡性淋巴瘤的风险很低。皮脂腺淋巴结瘤是一种罕见的良性唾液腺肿瘤，最常见于腮腺，组织学上以增生性淋巴样间质中皮脂腺分化的实体上皮巢和囊肿为定义。我们报告一个不寻常的病例ISFN出现在皮脂腺淋巴结瘤。据我们所知，这种联系以前没有报道过。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Hematopathology HEMATOLOGYPATHOLOGY-PATHOLOGY

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Journal of Hematopathology aims at providing pathologists with a special interest in hematopathology with all the information needed to perform modern pathology in evaluating lymphoid tissues and bone marrow. To this end the journal publishes reviews, editorials, comments, original papers, guidelines and protocols, papers on ancillary techniques, and occasional case reports in the fields of the pathology, molecular biology, and clinical features of diseases of the hematopoietic system. The journal is the unique reference point for all pathologists with an interest in hematopathology. Molecular biologists involved in the expanding field of molecular diagnostics and research on lymphomas and leukemia benefit from the journal, too. Furthermore, the journal is of major interest for hematologists dealing with patients suffering from lymphomas, leukemias, and other diseases. The journal is unique in its true international character. Especially in the field of hematopathology it is clear that there are huge geographical variations in incidence of diseases. This is not only locally relevant, but due to globalization, relevant for all those involved in the management of patients.