Effects of deep brain stimulation on personality and executive function in Parkinson's disease.

Q3 Medicine

Dementia e Neuropsychologia Pub Date : 2025-09-05 eCollection Date: 2025-01-01 DOI:10.1590/1980-5764-DN-2024-0254

Thayná Laís de Souza Arten, Amer Cavalheiro Hamdan

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引用次数: 0

Abstract

Parkinson's disease (PD) is associated with cognitive and personality changes that extend beyond its characteristic motor symptoms.

Objective: To analyze the effects of subthalamic nucleus deep brain stimulation (STN-DBS) on executive function (EF) and personality (The Five-Factor Model - FFM) in PD patients, comparing outcomes between those treated solely with medication and those receiving both medication and STN-DBS.

Methods: A total of 69 participants were divided into three groups: DBS, medication, and control. Evaluations included inventories, tests, and scales, with results summarized in tables highlighting sociodemographic variables and screening outcomes.

Results: Cognitive assessments indicated that the DBS group exhibited slightly lower cognitive scores compared to the medication group. Personality differences were minimal, with only extraversion demonstrating significance.

Conclusion: STN-DBS did not have a significant impact on executive functions or personality traits in patients with PD. These results highlight the importance of considering broader cognitive and neuropsychiatric factors when evaluating patient outcomes following DBS.

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脑深部电刺激对帕金森病患者人格和执行功能的影响。

帕金森病（PD）与认知和人格改变有关，这些改变超出了其特有的运动症状。目的：分析丘脑底核深部脑刺激（STN-DBS）对PD患者执行功能（EF）和人格（五因素模型- FFM）的影响，比较单纯药物治疗组和同时接受STN-DBS治疗组的预后。方法：69例受试者分为DBS组、药物组和对照组。评估包括清单、测试和量表，结果汇总在强调社会人口变量和筛选结果的表格中。结果：认知评估显示，DBS组的认知评分略低于药物组。性格差异很小，只有外向性表现出显著性。结论：STN-DBS对PD患者的执行功能和人格特征无显著影响。这些结果强调了在评估DBS后患者预后时考虑更广泛的认知和神经精神因素的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dementia e Neuropsychologia Medicine-Geriatrics and Gerontology

CiteScore

2.20

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： Dementia top Neuropsychologia the official scientific journal of the Cognitive Neurology and Ageing Department of the Brazilian Academy of Neurology and of the Brazilian Association of Geriatric Neuropsychiatry, is published by the "Associação Neurologia Cognitiva e do Comportamento", a nonprofit Brazilian association. Regularly published on March, June, September, and December since 2007.