Circadian Rhythms in Aging and Age-Related Neurogenerative Disease.

IF 2 Q4 CLINICAL NEUROLOGY

Current Sleep Medicine Reports Pub Date : 2025-12-01 Epub Date: 2025-05-17 DOI:10.1007/s40675-025-00336-w

Kirsi-Marja Zitting, Robin K Yuan

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引用次数: 0

Abstract

Purpose of review: Age-related changes in the circadian timing system may play a role in the development of disorders in older age. We review key aspects of the human circadian system that change with aging, discuss recent evidence of how changes in sleep and circadian rhythms manifest in neurodegenerative diseases, and summarize research on new therapies.

Recent findings: Several mechanisms have been proposed to underlie age-related changes in sleep and circadian rhythmicity. These mechanisms include changes in the suprachiasmatic nucleus, melatonin production, and light sensitivity as well as impaired glymphatic drainage, buildup of amyloid-beta, hypoxia from sleep-disordered breathing, and increased levels of orexin. While light-based therapies and lifestyle interventions have been under investigation for years, newer interventions include treatment with orexin antagonists and gamma stimulation to improve sleep and circadian rhythmicity.

Summary: Despite growing interest, our understanding of how sleep and circadian rhythms contribute to the development of age-related neurodegenerative diseases is still limited. More research is needed to understand the bidirectional relationship between circadian rhythms, sleep, and neurodegenerative diseases to develop targeted interventions.

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衰老和年龄相关神经退行性疾病的昼夜节律。

综述的目的：与年龄相关的昼夜节律系统的变化可能在老年疾病的发展中发挥作用。我们回顾了人类昼夜节律系统随年龄变化的关键方面，讨论了睡眠和昼夜节律变化如何在神经退行性疾病中表现出来的最新证据，并总结了新疗法的研究。最近的发现：已经提出了几种机制来解释与年龄相关的睡眠和昼夜节律变化。这些机制包括视交叉上核的变化、褪黑素的产生、光敏感性以及淋巴排水受损、淀粉样蛋白的积累、睡眠呼吸障碍引起的缺氧以及食欲素水平的增加。虽然以光为基础的疗法和生活方式干预已被研究多年，但较新的干预措施包括使用食欲素拮抗剂和伽马刺激来改善睡眠和昼夜节律。摘要：尽管人们对睡眠和昼夜节律如何促进与年龄相关的神经退行性疾病的发展越来越感兴趣，但我们对睡眠和昼夜节律如何促进与年龄相关的神经退行性疾病发展的理解仍然有限。需要更多的研究来了解昼夜节律、睡眠和神经退行性疾病之间的双向关系，以制定有针对性的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Sleep Medicine Reports Medicine-Pulmonary and Respiratory Medicine

CiteScore

2.50

自引率

5.60%

发文量

期刊介绍： Current Sleep Medicine Reports aims to review the most important, recently published articles in the field of sleep medicine. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of sleep conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as insomnia, narcolepsy, sleep apnea, circadian rhythm disorders, and parasomnias. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.