Immunomodulatory activity of isolated phenanthrene and dihydrophenanthrene derivatives (coelotrinins A-L) from Coelogyne trinervis

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-09-14 DOI:10.1016/j.phytochem.2025.114676

Chattarika Pengdee , Adeline Dehlinger , May Thazin Thant , Al Arofatus Naini , Sofa Fajriah , Yanyong Punpreuk , Wanwimon Mekboonsonglarp , Virunh Kongkatitham , Siriporn Jungsuttiwong , Chatchai Chaotham , Chotima Böttcher , Boonchoo Sritularak

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Abstract

Twelve previously undescribed compounds, named coelotrinins A-L (1–12), comprising eight dihydrophenanthrene derivatives (1, 4–5, and 7–11), two phenanthrene derivatives (2–3), and two phenanthrene-dihydrophenanthrene derivatives (6 and 12), along with twenty-one known compounds (13–33), were isolated from the pseudobulbs of Coelogyne trinervis. The structures were elucidated via spectroscopic data analysis, and their configurations were determined by optical rotation values and by comparing experimental and calculated electronic circular dichroism curves. Among these compounds, four compounds (1, 16, 23, and 24) showed immunomodulatory effects by inhibiting LPS-induced TNF-α production in THP-1 monocytes. Only coelotrinin A (1) exhibited an immunomodulatory effect with suppression on human peripheral blood mononuclear cells isolated from patients with multiple sclerosis.

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从黄芩中分离的菲和二氢菲衍生物（黄芩苷A-L）的免疫调节活性。

从假球茎中分离到12个先前未被描述的化合物，命名为coelotrinins A-L(1-12)，包括8个二氢菲衍生物（1,4 - 5,7 -11），2个菲衍生物（2-3）和2个菲-二氢菲衍生物（6和12），以及21个已知化合物（13-33）。通过光谱数据分析对其结构进行了分析，并通过旋光度值和实验与计算的电子圆二色性曲线的比较确定了其构型。在这些化合物中，化合物1、16、23和24通过抑制lps诱导的THP-1单核细胞中TNF-α的产生而具有免疫调节作用。只有coelotrinin A(1)表现出免疫调节作用，抑制多发性硬化症患者外周血单个核细胞。

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.