E Bevilacqua, C R R Rocha, H W Yung, G J Burton, A R Lorenzon
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引用次数: 0
Abstract
Disruption of endoplasmic reticulum (ER) homeostasis causes a condition known as "ER stress" that triggers a finely regulated response, the unfolded protein response (UPR), primarily associated with the restoration of normal ER function. Although the UPR is principally a pro-survival process, sustained and/or prolonged stress can induce cell death. ER stress has been observed in various gestational diseases and is associated with poor pregnancy outcomes. In this review, we examined the role of stromal cell-derived factor 2 (SDF2) in the UPR, particularly in placental cells. We highlight recent findings that enhance our understanding of the underlying molecular mechanisms and their influence on the balance between cell survival and death. Exploring how SDF2 affects cell survival and death during ER stress may be vital for developing therapeutic strategies aimed at preventing adverse disease outcomes during pregnancy.
期刊介绍：
Placenta publishes high-quality original articles and invited topical reviews on all aspects of human and animal placentation, and the interactions between the mother, the placenta and fetal development. Topics covered include evolution, development, genetics and epigenetics, stem cells, metabolism, transport, immunology, pathology, pharmacology, cell and molecular biology, and developmental programming. The Editors welcome studies on implantation and the endometrium, comparative placentation, the uterine and umbilical circulations, the relationship between fetal and placental development, clinical aspects of altered placental development or function, the placental membranes, the influence of paternal factors on placental development or function, and the assessment of biomarkers of placental disorders.
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