{"title":"Respiratory Sarcopenia Is Associated With Postoperative Pulmonary Complications in Patients With Esophageal Cancer.","authors":"Kakeru Hasegawa, Masahiko Wakasa, Kazuki Okura, Yusuke Takahashi, Yushi Nagaki, Yusuke Sato, Akiyuki Wakita, Yuji Kasukawa, Naohisa Miyakoshi","doi":"10.1002/jso.70092","DOIUrl":null,"url":null,"abstract":"<p><p>Esophagectomy for esophageal cancer carries a high risk of postoperative pulmonary complications (PPCs), which impact mortality and quality of life. Respiratory sarcopenia, characterized by decreased respiratory muscle strength and mass, may contribute to PPC risk, but its role remains unclear. This retrospective cohort study analyzed 79 patients who underwent esophagectomy (June 2021-June 2024). Respiratory sarcopenia was defined as the presence of both low maximum inspiratory pressure (MIP) and diaphragm thickness (DT), assessed using a respiratory pressure meter and ultrasound. PPCs were classified using the Clavien-Dindo grade > II. The incidence of PPCs was higher in patients with respiratory sarcopenia than those without (55% vs. 27%), based on unadjusted proportions. Bayesian logistic regression adjusting for age, smoking, and nutritional status showed that respiratory sarcopenia was strongly associated with PPCs (adjusted mean odds ratio: 2.79; 95% credible interval: 0.75-7.37), particularly pneumonia and prolonged hospitalization. Identifying and addressing respiratory sarcopenia preoperatively through inspiratory muscle training and nutritional support may reduce PPC risk and improve outcomes.</p>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Surgical Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jso.70092","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Esophagectomy for esophageal cancer carries a high risk of postoperative pulmonary complications (PPCs), which impact mortality and quality of life. Respiratory sarcopenia, characterized by decreased respiratory muscle strength and mass, may contribute to PPC risk, but its role remains unclear. This retrospective cohort study analyzed 79 patients who underwent esophagectomy (June 2021-June 2024). Respiratory sarcopenia was defined as the presence of both low maximum inspiratory pressure (MIP) and diaphragm thickness (DT), assessed using a respiratory pressure meter and ultrasound. PPCs were classified using the Clavien-Dindo grade > II. The incidence of PPCs was higher in patients with respiratory sarcopenia than those without (55% vs. 27%), based on unadjusted proportions. Bayesian logistic regression adjusting for age, smoking, and nutritional status showed that respiratory sarcopenia was strongly associated with PPCs (adjusted mean odds ratio: 2.79; 95% credible interval: 0.75-7.37), particularly pneumonia and prolonged hospitalization. Identifying and addressing respiratory sarcopenia preoperatively through inspiratory muscle training and nutritional support may reduce PPC risk and improve outcomes.
期刊介绍:
The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.