Redox responsive functionalised mesoporous silica nanoparticle for targeted drug delivery of doxorubicin.

IF 3.9 4区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Targeting Pub Date : 2025-09-17 DOI:10.1080/1061186X.2025.2560592

Seyedeh Sahar Mojtabazadeh, Mahnoosh Samadi, Sahra Perseh, Saba Saei, Reza Bafkari, Fatemeh Atyabi, Rassoul Dinarvand

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引用次数: 0

Abstract

Mesoporous silica nanoparticles (MSNs) have been studied for the delivery of anticancer drugs because of their unique mesoporous channels. In this study, Biotin was used as a targeting moiety of MSNs for the purpose of breast cancer cell targeting, and then, Gelatine grafting onto the surface of MSNs was carried out using glutaraldehyde-mediated cross-linking as a capping layer. Dynamic light scattering (DLS), Zeta potential change, infra-red spectroscopy (FT-IR), nitrogen adsorption and desorption (BET), and transmission electron microscopy (TEM) was used for the characterisation of size, morphology and other features related to the fabricated nanoparticles (NPs). The gelatine/biotin coated MSNs (MSN@Bio-Gel) were loaded with Doxorubicin (DOX), followed by assessing its drug loading and release behaviour. In vitro experiments were carried out for exploring the antitumor effect of DOX-MSN@Bio-Gel. The size of NPs prepared in this study was in the range of 178-286 nm. The MTT assay showed suitable anticancer activity of the NPs.Confocal microscopy showed that gelatine-coated, biotin-targeted MSNs had higher cell uptake into MCF-7 cancer cells.

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氧化还原反应功能化介孔二氧化硅纳米颗粒靶向药物递送阿霉素。

介孔二氧化硅纳米颗粒（MSNs）由于其独特的介孔通道而被研究用于抗癌药物的递送。本研究以生物素作为msn的靶向部分，靶向乳腺癌细胞，然后以戊二醛介导的交联作为盖层，在msn表面进行明胶接枝。采用动态光散射（DLS）、Zeta电位变化、红外光谱（FT-IR）、氮吸附和解吸（BET）和透射电子显微镜（TEM）对制备的纳米颗粒（NPs）的尺寸、形貌和其他特征进行了表征。明胶/生物素包被的msn （MSN@Bio-Gel）装载阿霉素（DOX），随后评估其药物装载和释放行为。通过体外实验探讨DOX-MSN@Bio-Gel的抗肿瘤作用。本研究制备的NPs的大小在178 ~ 286 nm之间。MTT实验显示NPs具有良好的抗癌活性。共聚焦显微镜显示，明胶包被、生物素靶向的msn对MCF-7癌细胞有更高的细胞摄取。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Drug Targeting 医学-药学

CiteScore

9.10

自引率

0.00%

发文量

165

审稿时长

2 months

期刊介绍： Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs. Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns.