Exercise-Induced Epigenetic Modifications: Implications for Healthy Aging.

IF 2.2 4区医学 Q2 SPORT SCIENCES

International journal of sports medicine Pub Date : 2025-10-09 DOI:10.1055/a-2702-4789

Qi Yang, Yue Hu, Bing Zhang, Weihao Hong

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引用次数: 0

Abstract

Aging is a complex biological process driven by the dynamic interplay among genetic, environmental, and lifestyle factors. Advances in epigenetics have significantly deepened our understanding of the molecular mechanisms underlying aging, underscoring the critical roles of reversible modifications such as DNA methylation, histone modifications, and noncoding RNA regulation. Emerging evidence suggests that exercise is a potent modulator of these epigenetic processes, capable of reshaping the epigenetic landscape to restore cellular homeostasis, modulate gene expression, and enhance physiological resilience. This review systematically synthesizes current knowledge on how exercise modulates epigenetic mechanisms implicated in aging and delineates the distinct epigenetic adaptations induced by variations in exercise modality, intensity, and duration. By integrating these molecular insights, this review provides a comprehensive mechanistic framework linking exercise-induced epigenetic remodeling to healthy aging, and underscores exercise as a promising intervention to counteract aging-related functional decline and disease progression.

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运动诱导的表观遗传修饰：对健康衰老的影响。

衰老是一个复杂的生物过程，受遗传、环境和生活方式等因素的动态相互作用驱动。表观遗传学的进展极大地加深了我们对衰老分子机制的理解，强调了DNA甲基化、组蛋白修饰和非编码RNA调控等可逆修饰的关键作用。新出现的证据表明，运动是这些表观遗传过程的有效调节剂，能够重塑表观遗传景观，恢复细胞稳态，调节基因表达，增强生理弹性。这篇综述系统地综合了目前关于运动如何调节与衰老有关的表观遗传机制的知识，并描述了由运动方式、强度和持续时间的变化引起的不同的表观遗传适应。通过整合这些分子见解，本综述提供了一个将运动诱导的表观遗传重塑与健康衰老联系起来的综合机制框架，并强调运动是对抗衰老相关功能下降和疾病进展的有希望的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of sports medicine 医学-运动科学

CiteScore

4.80

自引率

4.00%

发文量

111

审稿时长

3-8 weeks

期刊介绍： The IJSM provides a forum for the publication of papers dealing with both basic and applied information that advance the field of sports medicine and exercise science, and offer a better understanding of biomedicine. The journal publishes original papers, reviews, short communications, and letters to the Editors.