Inverse Association Between D-Dimer Levels and Glasgow Coma Scale Scores in Hemorrhagic Stroke Patients: A Cross-Sectional Study.

IF 2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
International Journal of General Medicine Pub Date : 2025-09-11 eCollection Date: 2025-01-01 DOI:10.2147/IJGM.S540186
Dapeng Dai, Yong Sun, Hongwei Zhang, Aimin Li
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引用次数: 0

Abstract

Aim: Hemorrhagic stroke (HS) represents one of the major causes of death in China. The research work focuses on the correlation between Glasgow Coma Scale (GCS) score and D-dimer level, and the role of modified factors such as platelet count in HS patients.

Methods: This was a cross-sectional study that was conducted at the First People's Hospital of Lianyungang, Lianyungang City, China. HS Patients were divided into three groups according to their GCS scores: GCS < 9 (severe, n = 43), 9 ≤ GCS < 13 (moderate, n = 97), and GCS ≥ 13 (mild, n = 487).

Results: The analysis comprised 627 participants. D-dimer levels were 142.0 ng/mL on average. The average GCS score was 13.6, and the average age was 61.0 years. The three GCS groups showed significant differences in D-dimer concentrations, diastolic blood pressure (DBP), and systolic blood pressure (SBP) (P < 0.001, P = 0.028, and P = 0.005, respectively). Among severe GCS scores (<9), the D-dimer level was the highest at 237.0 ng/mL. After adjustment for possible confounders, the D-dimer concentrations were significantly lower in the moderate and mild GCS groups than in the severe group (P = 0.030 and P = 0.038, respectively). In the stratified analysis, the association between GCS categories and D-dimer levels was stronger among participants with low platelet counts (<194 × 10^9/L; P for interaction = 0.017).

Conclusion: This study reveals a significant inverse association between D-dimer levels and GCS scores in HS patients, especially those with lower platelet counts. Elevated D-dimer levels may reflect coagulation and fibrinolysis activation, contributing to worse outcomes. Clinically, more attention and monitoring should be paid to the HS patients with elevated D-dimer levels.

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出血性卒中患者d -二聚体水平与格拉斯哥昏迷评分的负相关:一项横断面研究
目的:出血性中风(HS)是中国主要的死亡原因之一。重点研究格拉斯哥昏迷量表(GCS)评分与d -二聚体水平的相关性,以及血小板计数等修饰因子在HS患者中的作用。方法:本研究为横断面研究,在中国连云港市连云港市第一人民医院进行。HS患者根据GCS评分分为3组:GCS < 9(重度,n = 43)、9≤GCS < 13(中度,n = 97)、GCS≥13(轻度,n = 487)。结果:共纳入627名参与者。d -二聚体水平平均为142.0 ng/mL。平均GCS评分为13.6,平均年龄为61.0岁。GCS组d -二聚体浓度、舒张压(DBP)、收缩压(SBP)差异均有统计学意义(P < 0.001、P = 0.028、P = 0.005)。结论:本研究揭示了HS患者,尤其是血小板计数较低的患者,d -二聚体水平与GCS评分呈显著负相关。升高的d -二聚体水平可能反映凝血和纤溶激活,导致更糟糕的结果。临床上对伴有d -二聚体升高的HS患者应给予更多的关注和监测。
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来源期刊
International Journal of General Medicine
International Journal of General Medicine Medicine-General Medicine
自引率
0.00%
发文量
1113
审稿时长
16 weeks
期刊介绍: The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.
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