Efficacy of intraovarian injection of autologous platelet-rich plasma on outcome of in vitro fertilization in women with poor ovarian response: A systematic review.

Abstract

Background: The beneficial and long-term effects of ovarian platelet-rich plasma (PRP) in assisted reproductive technology cycles are still debatable.

Objective: The aim of the current study is to determine the effect of ovarian PRP on the outcome of in vitro fertilization in women with poor ovarian response.

Materials and methods: This is a systematic review conducted to address the research question through a structured search process. We searched databases including PubMed, ScienceDirect, Scopus, Web of Science, Embase, Cochrane, and Google Scholar search engine using keywords such as "clinical pregnancy", "live birth", "miscarriage", "poor ovarian response", "platelet-rich plasma", and "in vitro fertilization". The search was conducted without a time limit until December 20, 2024. After screening the titles, abstracts, and full texts of 6646 studies, 14 studies were ultimately selected for inclusion in the review.

Results: In 3 studies, no significant effect was observed on abortion rates, but in 1 study, no abortions were reported in the intervention group, raising concerns about the possible role of this procedure. In 5 studies, PRP significantly increased pregnancy success with in vitro fertilization. In contrast, 6 studies found this effect to be non-significant, and 2 reported inconclusive results. In terms of live birth, 5 studies showed a positive effect of PRP, but 3 studies reported non-significant results, and 2 studies reported inconclusive results. One study showed an increase in ongoing pregnancy rates in the PRP group, and 2 studies showed an increase in implantation.

Conclusion: The effectiveness of ovarian PRP in infertility treatment remains unclear due to conflicting results.