Autism spectrum traits in adults with attention-deficit/hyperactivity disorder (ADHD): a hidden multifaceted phenotype marked by affective comorbidity, emotional dysregulation, and chronobiological disturbances.

IF 3.7 3区 医学 Q1 CLINICAL NEUROLOGY
Giulio Emilio Brancati, Ugo De Rosa, Anna Magnesa, Irene Cocciaro, Elena Costagli, Anna Iriti, Berenice Rimoldi, Matteo Vedovelli, Pierpaolo Medda, Elisa Schiavi, Giulio Perugi
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Abstract

Background: Autism spectrum disorder (ASD) is a commonly observed comorbidity in children with attention-deficit/hyperactivity disorder (ADHD). Nevertheless, the impact of autism spectrum traits on clinical presentation and comorbidities in adults with ADHD remains largely underexplored.

Methods: 105 adults with ADHD were recruited at the outpatient service of the Psychiatry Unit 2 at Pisa University Hospital and subdivided according to screening for ASD based on the Autism-Spectrum Quotient (AQ). Comparative analyses were performed for sociodemographic and clinical variables.

Results: Participants with a positive screening for ASD (N = 23, 21.9%) were more frequently females, had a higher age at first clinical referral, higher comorbidity rates with mood and anxiety disorders, particularly social anxiety, and a lower rate of cannabis use disorder. They showed significantly greater severity of ADHD and emotional dysregulation, worse personality and interpersonal functioning, more depressive, cyclothymic and anxious temperamental dispositions, more pathological personality traits, increased biological rhythm disturbances and evening chronotype.

Conclusions: Autism spectrum traits are commonly reported in adults with ADHD and may be associated with female sex and a complex clinical presentation characterized by affective comorbidity, more severe emotional dysregulation and chronobiological disturbances.

成人注意力缺陷/多动障碍(ADHD)的自闭症谱系特征:一种隐藏的多方面表型,以情感共病、情绪失调和时间生物学障碍为特征。
背景:自闭症谱系障碍(ASD)是儿童注意缺陷/多动障碍(ADHD)的常见合并症。然而,自闭症谱系特征对成年ADHD患者的临床表现和合并症的影响在很大程度上仍未得到充分研究。方法:在比萨大学医院精神病学第二科门诊招募了105名ADHD成人患者,并根据自闭症谱系商(AQ)筛查ASD进行细分。对社会人口学和临床变量进行比较分析。结果:ASD筛查阳性的参与者(N = 23, 21.9%)更多是女性,首次临床转诊时年龄较高,与情绪和焦虑障碍(尤其是社交焦虑)的合并症发生率较高,大麻使用障碍的发生率较低。他们表现出更严重的注意力缺陷多动症和情绪失调,更差的人格和人际关系功能,更多的抑郁,周期性和焦虑的气质倾向,更多的病态人格特征,更多的生物节律障碍和夜间睡眠类型。结论:自闭症谱系特征在成年ADHD患者中普遍存在,可能与女性性别和复杂的临床表现有关,其特征是情感合并症、更严重的情绪失调和时间生物学障碍。
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来源期刊
CiteScore
8.80
自引率
4.30%
发文量
154
审稿时长
6-12 weeks
期刊介绍: The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.
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