Multi-ingredient supplementation for combating sarcopenia and polymorbidity.

IF 3.5 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Joshua P Nederveen, Mats I Nilsson, Mark A Tarnopolsky
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引用次数: 0

Abstract

Purpose of review: We discuss the premise and potential of multi-ingredient supplements (MIS) in the treatment of complex skeletal muscle (SkM) pathologies, and provide an updated review of literature on nutraceuticals in sarcopenia and sarcopenic obesity (SO) management, with an emphasis on single- vs. multi-ingredient protein-based formulations.

Recent findings: Several meta-analyses have confirmed the synergistic benefits of combining resistance training (RT) with dietary protein supplementation in older adults with sarcopenia or physical frailty, with a potential ceiling effect at 1.5-1.7 g PRO/kg BW/day.Single-ingredient supplements with proven synergism with RT and clinical relevance for sarcopenia treatment include the major milk proteins (whey and/or casein) and creatine monohydrate. Vitamin D 3 , calcium, and/or n -3 polyunsaturated fatty acids are also recommended for mitigating concurrent micronutrient deficiencies, bone loss, and inflammation. More evidence is needed to justify monotherapy with leucine or leucine metabolites over high-quality protein sources.RCTs have demonstrated superiority of whey-based MIS compared to isocaloric and isonitrogenous placebo for enhancing SkM growth in both younger and older persons, including obese and nonobese sarcopenic subgroups, as confirmed by in vivo body composition and/or biopsy sampling.Multi-ingredient formulations containing high-quality milk proteins, creatine monohydrate, vitamin D 3 , calcium, and n -3 polyunsaturated fatty acids may therefore be recommended in the multimodal treatment of sarcopenia and sarcopenic obesity.

Summary: Resistance training is the first-line treatment for musculoskeletal conditions and improves lean body mass, strength, and function in sarcopenia patients. Increased protein intake augments RT-induced muscle anabolism across clinical subpopulations, with recent evidence suggesting superiority of multi vs. single-ingredient protein-based supplements.

多成分补充,对抗肌肉减少症和多发性疾病。
综述的目的:我们讨论了多成分补充剂(MIS)在治疗复杂骨骼肌(SkM)病变中的前提和潜力,并提供了关于肌少症和肌少性肥胖(SO)管理的营养药品的最新文献综述,重点是单成分与多成分蛋白质制剂。最近的发现:一些荟萃分析已经证实,在患有肌肉减少症或身体虚弱的老年人中,将阻力训练(RT)与膳食蛋白质补充相结合具有协同效益,其潜在的上限效应为1.5-1.7 g PRO/kg BW/天。经证实与肌少症治疗具有协同作用和临床相关性的单一成分补充剂包括主要的牛奶蛋白(乳清和/或酪蛋白)和一水肌酸。维生素D3、钙和/或n-3多不饱和脂肪酸也被推荐用于减轻同时发生的微量营养素缺乏、骨质流失和炎症。需要更多的证据来证明亮氨酸或亮氨酸代谢物单药治疗优于优质蛋白质来源。随机对照试验已经证明,乳清基MIS在促进年轻人和老年人(包括肥胖和非肥胖肌肉减少亚组)SkM生长方面优于等热量和等氮安慰剂,这一点已被体内成分和/或活检取样证实。因此,含有优质牛奶蛋白、一水肌酸、维生素D3、钙和n-3多不饱和脂肪酸的多成分配方可能被推荐用于肌肉减少症和肌肉减少性肥胖的多模式治疗。摘要:阻力训练是肌肉骨骼疾病的一线治疗方法,可以改善肌肉减少症患者的瘦体重、力量和功能。增加蛋白质摄入量增加了临床亚群中rt诱导的肌肉合成代谢,最近的证据表明多成分蛋白质补充剂优于单一成分蛋白质补充剂。
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来源期刊
CiteScore
5.30
自引率
6.50%
发文量
116
审稿时长
6-12 weeks
期刊介绍: A high impact review journal which boasts an international readership, Current Opinion in Clinical Nutrition and Metabolic Care offers a broad-based perspective on the most recent and exciting developments within the field of clinical nutrition and metabolic care. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include protein, amino acid metabolism and therapy, lipid metabolism and therapy, nutrition and the intensive care unit and carbohydrates. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.
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