Associations Between Exposure to Extreme Ambient Heat During Periconception and Gastroschisis in Georgia, USA: A Population-Based, Matched Case–Control Study

IF 1.6 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Birth Defects Research Pub Date : 2025-09-17 DOI:10.1002/bdr2.2531

Sarah LaPointe, Xiaping Zheng, Vijaya Kancherla, Howard H. Chang, Audrey J. Gaskins

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Abstract

Introduction

Epidemiologic evidence on extreme ambient temperature exposures and gastroschisis is limited and conflicting.

Methods

This case–control study included records for liveborn infants in the state of Georgia, USA from 2008 to 2017. Cases included any live births with isolated gastroschisis matched 1:4 to controls free of birth defects based on county of residence and maternal age. Exposure to extreme ambient heat was defined using the 95th percentile of the county-level climatological temperature averages during periconception. Multivariable conditional logistic regression models estimated the adjusted odds ratios (aORs) and 95% confidence intervals (95% CI) for the associations between extreme ambient heat exposure during periconception and isolated gastroschisis.

Results

There were 191 cases of isolated gastroschisis and 764 controls in our study. Compared to no days of extreme heat exposure in the periconception period, exposure to 1–3, 4–7, and ≥ 8 days of extreme apparent temperatures was associated with 19% (aOR = 1.19; 95% CI 1.03, 1.38), 42% (aOR = 1.42; 95% CI 1.06, 1.91), and 70% (aOR = 1.70; 95% CI 1.09, 2.63) higher odds of isolated gastroschisis, respectively. Exposure to two or more and three or more consecutive days of extreme apparent temperature was associated with 58% (aOR = 1.58; 95% CI 1.08, 2.30) and 66% (aOR = 1.66; 95% CI 1.14, 2.41) higher odds of isolated gastroschisis, respectively.

Conclusions

We observed a positive association between exposure to extreme ambient heat and the odds of isolated gastroschisis. These findings highlight the need for more research on these associations and potential interventions to protect mothers and babies.

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在美国乔治亚州，孕周暴露于极端环境高温与腹裂之间的关系：一项基于人群的匹配病例对照研究。

关于极端环境温度暴露和胃裂的流行病学证据有限且相互矛盾。方法：本病例对照研究纳入了2008年至2017年美国佐治亚州活产婴儿的记录。病例包括根据居住县和产妇年龄与无出生缺陷的对照组匹配1:4的孤立性腹裂活产婴儿。暴露于极端环境高温的定义是使用围孕期县级气候温度平均值的第95个百分位数。多变量条件logistic回归模型估计了围孕期极端环境热暴露与孤立性胃裂之间的校正优势比（aORs）和95%置信区间（95% CI）。结果：本组分离性腹裂191例，对照组764例。与感觉期无极端高温暴露天数相比，暴露于极端表面温度1-3、4-7和≥8天的患儿发生孤立性胃裂的几率分别增加19% （aOR = 1.19; 95% CI 1.03, 1.38）、42% （aOR = 1.42; 95% CI 1.06, 1.91）和70% （aOR = 1.70; 95% CI 1.09, 2.63）。暴露于连续两天或更长时间的极端表面温度和连续三天或更长时间的极端表面温度分别与58% （aOR = 1.58; 95% CI 1.08, 2.30）和66% （aOR = 1.66; 95% CI 1.14, 2.41）孤立性胃裂的几率增加相关。结论：我们观察到暴露于极端环境高温与孤立性胃裂的几率呈正相关。这些发现强调需要对这些关联和潜在的干预措施进行更多的研究，以保护母亲和婴儿。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.