Recent Progress in Hydrogen Sulfide-Generating Nanomedicines for Cancer Therapy: From Design to In Situ Generation

IF 3.9 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Bioconjugate Chemistry Pub Date : 2025-09-16 DOI:10.1021/acs.bioconjchem.5c00318

Kaiyue Song, , , Xinlin Jia, , , Feng Zhao, , , Fen Liu, , , Cong Jiang*, , and , Xianglong Li*,

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Abstract

Hydrogen sulfide (H₂S), once regarded solely as a toxic gas, has emerged as a star molecule for potential anticancer therapy. However, precise spatiotemporal control of H₂S delivery remains challenging due to rapid diffusion and systemic toxicity risks. Recent advances in nanotechnology have enabled the design of H₂S-generating nanomedicines (HSGNs) that address these limitations through stimuli-responsive in situ H₂S generation. Through engineered design, HSGNs with different in situ generation mechanisms (such as pH and GSH responses) can be designed to improve the controlled release of H₂S within cells effectively, and considerable efforts have been made to explore their multimodal synergistic effects in cancer therapy. This review systematically examines the development of HSGNs, focusing on material innovations, controlled-release strategies, and multimodal therapeutic applications in cancer treatment, and, finally, provides a prospective view of the future development of HSGNs to accelerate their practical clinical translation and application.

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用于癌症治疗的硫化氢生成纳米药物的最新进展：从设计到原位生成。

硫化氢（H2S）一度被认为是一种有毒气体，现在却成为潜在抗癌治疗的明星分子。然而，由于H2S的快速扩散和系统性毒性风险，对H2S输送的精确时空控制仍然具有挑战性。纳米技术的最新进展使得生成H2S的纳米药物（HSGNs）的设计能够通过刺激响应的原位生成H2S来解决这些限制。通过工程化设计，可以设计出具有不同原位生成机制（如pH和GSH反应）的hsgn，有效地改善细胞内H2S的控释，并对其在癌症治疗中的多模态协同作用进行了大量探索。本文对HSGNs的发展进行了系统的综述，重点介绍了HSGNs的材料创新、控释策略和多模式治疗在癌症治疗中的应用，并对HSGNs的未来发展进行了展望，以加快其临床实际转化和应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioconjugate Chemistry 生物-化学综合

CiteScore

9.00

自引率

2.10%

发文量

236

审稿时长

1.4 months

期刊介绍： Bioconjugate Chemistry invites original contributions on all research at the interface between man-made and biological materials. The mission of the journal is to communicate to advances in fields including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Bioconjugate Chemistry is intended to provide a forum for presentation of research relevant to all aspects of bioconjugates, including the preparation, properties and applications of biomolecular conjugates.