Nanoneedles in Biomedicine: Precision-Engineered Platforms for Theranostic Applications.

IF 5.5 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Biomaterials Science & Engineering Pub Date : 2025-09-16 DOI:10.1021/acsbiomaterials.5c00757

Narendran Sekar, Mathana Vetrivel P, Anisha Kabir, Kaviya Vijayalakshmi Babunagappan, Roey Elnathan, Swathi Sudhakar

引用次数: 0

Abstract

Cell engineering holds immense potential for treating complex diseases but is limited by immunogenic responses, low targeting potential, and high costs. Vertical nanoneedles, precisely engineered with a high aspect ratio, have emerged as a promising delivery vehicle to overcome these problems for minimally invasive drug delivery and cellular stimulation. This review critically examines recent advances in the design, fabrication, and application of nanoneedles for various purposes, with a primary focus on gene and drug delivery, biosensing, and cellular differentiation. Key findings highlight how the nanoneedles help in the transport of cell-impermeable biological molecules in a minimally invasive way for their efficient function in therapeutics or biosensing applications and their limitations. These applications extend to improving gene therapy and cellular-based treatments, making them a versatile tool in regenerative medicine.

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生物医学中的纳米针：用于治疗应用的精密工程平台。

细胞工程在治疗复杂疾病方面具有巨大的潜力，但受到免疫原性反应、低靶向潜力和高成本的限制。垂直纳米针，精确设计具有高宽高比，已经成为一种有前途的递送工具，以克服这些问题的微创药物递送和细胞刺激。本文综述了纳米针的设计、制造和应用的最新进展，主要集中在基因和药物传递、生物传感和细胞分化方面。关键发现强调了纳米针如何以微创方式帮助细胞不渗透生物分子的运输，以及它们在治疗或生物传感应用中的有效功能及其局限性。这些应用扩展到改善基因治疗和基于细胞的治疗，使它们成为再生医学的通用工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

期刊介绍： ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture