A Composite Dermal Matrix Comprising Ovine Forestomach Matrix and Hyaluronic Acid in the Treatment of Chronic Wounds Secondary to Calciphylaxis: A Case Series and Literature Review.

Abstract

Objective: To evaluate the efficacy and safety of composite ovine forestomach matrix and hyaluronic acid (OFM-HA) graft in facilitating tissue regeneration in atypical wounds secondary to calciphylaxis.

Methods: This retrospective case series included 3 patients with a total of 4 wounds (n = 4) who were diagnosed with wounds secondary to calciphylaxis in an outpatient setting. All wounds were treated with surgical debridement and a composite OFM-HA graft. Healing progress was monitored, and the total time to wound closure was assessed.

Results: All 4 wounds in the study achieved 100% wound healing, with a 12-week incidence of closure of 75%. The mean wound area at the time of OFM-HA treatment was 28.6 ± 26.9 cm2, with a mean depth of 0.2 ± 0.1 cm. The mean time to wound closure was 43.5 ± 37.0 days and all patients experienced a marked reduction in pain. No adverse events were reported, and all wounds remained healed after achieving 100% closure at final follow-up.

Conclusions: Ovine forestomach matrix and hyaluronic acid, in combination with wound bed preparation, were found to be safe and effective treatments for wounds associated with calciphylaxis; they may reduce the time to wound closure compared with traditional wound care and reduce complications associated with calciphylaxis-related wounds.