Five-year change in sleep duration and incident Alzheimer's Disease and Related Dementias among lower-income older adults

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-09-17 DOI:10.1002/alz.70678

Hui Shi, Loren Lipworth, Qian Xiao, Xijing Han, Michael Mumma, Laura M. Keohane, Danxia Yu, Corey J. Bolton, Derek B. Archer, Timothy J. Hohman, Kelsie M. Full

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引用次数: 0

Abstract

INTRODUCTION

Little is known about change in sleep duration over time and Alzheimer's Disease and Related Dementias (ADRD) risk.

METHODS

ADRD cases were identified among Southern Community Cohort Study participants enrolled in Medicare. Sleep duration was reported at enrollment and first study follow-up and categorized (short (< 7 hours), recommended (7-9) and long (> 9)), change was calculated between timepoints. Adjusted Cox proportional hazards regression was used to estimate hazard ratios (HRs, 95% CIs) for incident ADRD.

RESULTS

We identified 2,093 ADRD cases among 17,945 participants. Compared to maintaining optimal sleep duration (7-9 hours) over 5 years, suboptimal changes were associated with 20-69% greater ADRD risk: adjusted HR (95% CI) was 1.50 (1.23-1.82) for long-recommended, 1.56 (1.21-2.01) for long-long, 1.69 (1.25-2.27) for long-short, 1.49 (1.16-1.91) for short-long, and 1.20 (1.06-1.36) for short-short.

DISCUSSION

Suboptimal 5-year change in sleep durations were associated with ADRD risk among lower-income adults underrepresented in ADRD research.

Highlights

The study calculated 5-year change in sleep duration in a large community-based cohort of predominately lower-income adults.
Cases of Alzheimer's Disease and Related Dementias (ADRD) were ascertained from Medicare claims data among 17,945 participants with up to 12 years of follow-up.
Compared to maintaining 7-9 hours of sleep, older adults with suboptimal sleep categories were consistently at a greater risk of ADRD.

Abstract Image

查看原文本刊更多论文

低收入老年人5年睡眠时间的变化与阿尔茨海默病及相关痴呆的发病率

导读：随着时间的推移，睡眠时间的变化与阿尔茨海默病和相关痴呆（ADRD）风险的关系知之甚少。方法：在南方社区队列研究纳入医疗保险的参与者中确定ADRD病例。在入组和第一次研究随访时报告睡眠时间，并将其分类（短(9)），计算时间点之间的变化。采用校正Cox比例风险回归估计ADRD事件的风险比（hr, 95% ci）。结果：我们在17945名参与者中确定了2093例ADRD病例。与5年内保持最佳睡眠时间（7-9小时）相比，次优改变与20-69%的ADRD风险增加相关：长期推荐的调整HR （95% CI）为1.50(1.23-1.82)，长推荐的为1.56(1.21-2.01)，长推荐的为1.69(1.25-2.27)，短推荐的为1.49(1.16-1.91)，短推荐的为1.20（1.06-1.36）。讨论：在ADRD研究中未被充分代表的低收入成年人中，5年睡眠时间的次优变化与ADRD风险相关。重点：该研究计算了以社区为基础的以低收入成年人为主的大型队列中5年睡眠时间的变化。在长达12年的随访中，从17,945名参与者的医疗保险索赔数据中确定了阿尔茨海默病和相关痴呆（ADRD）病例。与保持7-9小时的睡眠相比，睡眠不佳的老年人患ADRD的风险一直更大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.