Electrochemical Drug Delivery of Plant-Derived Therapeutics via a Silica–Polysaccharide Electrode for Colorectal Cancer Inhibition

IF 3.3 3区材料科学 Q3 CHEMISTRY, PHYSICAL

Silicon Pub Date : 2025-07-17 DOI:10.1007/s12633-025-03401-9

Yanbin Chen, Xiaodong Xu, Xin Liu, Xinye Hu

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Abstract

Colorectal cancer, a highly prevalent malignant tumor on a global scale, requires the development of novel therapeutic strategies that are both highly efficient and less toxic. This study presents a novel electro-responsive drug delivery system for colorectal cancer therapy. The synthesized composite exhibited distinct redox activity in 0.1 M PBS (pH 7.0), with an enhanced oxidation peak current (0.65 mA) compared to the drug-free matrix, indicating improved electron transfer upon loading compound 1. Fluorescence intensity significantly increased to ~ 290 a.u. (λ_em ≈ 575 nm), verifying successful drug encapsulation. Electrochemical impedance spectroscopy further confirmed increased charge transfer resistance (Rct ≈ 5950 Ω), suggesting stable drug immobilization. Time-resolved fluorescence analysis revealed over 95% drug release within 320 min in PBS (pH 6.0), while applied potential and pH modulated release efficiency, reaching > 95% at 0.8 V and pH 2.0, respectively. In vitro CCK-8 assays demonstrated that Glucose–MPTMS@CP1@1 significantly inhibited proliferation of HCT116 and SW480 cells in a time-dependent manner, with stronger effects observed in HCT116 (P < 0.01). These results highlight Glucose–MPTMS@CP1@1 as a promising electrochemically controlled, pH-responsive platform for targeted colorectal cancer therapy.

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植物源药物通过硅多糖电极的电化学递送抑制结直肠癌

结直肠癌是一种全球范围内高度流行的恶性肿瘤，需要开发高效、低毒性的新型治疗策略。本研究提出一种新型的电反应给药系统用于结直肠癌治疗。合成的复合物在0.1 M PBS （pH 7.0）中表现出明显的氧化还原活性，与不含药物的基质相比，氧化峰电流（0.65 mA）增强，表明负载化合物1后电子转移得到改善。荧光强度显著增加至~ 290 a.u (λ_em≈575 nm)，证明药物包封成功。电化学阻抗谱进一步证实电荷转移电阻增加（Rct≈5950 Ω），表明药物固定稳定。时间分辨荧光分析显示，在PBS （pH 6.0）中，320 min内药物释放超过95%，而施加电位和pH调节释放效率，在0.8 V和pH 2.0时分别达到95%。体外CCK-8实验表明，葡萄糖- MPTMS@CP1@1显著抑制HCT116和SW480细胞的增殖，并呈时间依赖性，其中对HCT116的抑制作用更强（P < 0.01）。这些结果强调葡萄糖- MPTMS@CP1@1是一种有前途的电化学控制，ph响应平台，用于靶向结直肠癌治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Silicon CHEMISTRY, PHYSICAL-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

5.90

自引率

20.60%

发文量

685

审稿时长

>12 weeks

期刊介绍： The journal Silicon is intended to serve all those involved in studying the role of silicon as an enabling element in materials science. There are no restrictions on disciplinary boundaries provided the focus is on silicon-based materials or adds significantly to the understanding of such materials. Accordingly, such contributions are welcome in the areas of inorganic and organic chemistry, physics, biology, engineering, nanoscience, environmental science, electronics and optoelectronics, and modeling and theory. Relevant silicon-based materials include, but are not limited to, semiconductors, polymers, composites, ceramics, glasses, coatings, resins, composites, small molecules, and thin films.