Silver nanoparticles as a triple-action agent: therapeutic potential in skin cancer, skin infections, and antioxidant activity

IF 3.674 4区工程技术 Q1 Engineering

Applied Nanoscience Pub Date : 2025-09-17 DOI:10.1007/s13204-025-03119-5

Karrar R. Mohammed, Ridha A. Hussein, Hussein Abbood Awad, Mohammed S. Al-Hindawi

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Abstract

The increasing incidence of skin cancer, antimicrobial resistance, and oxidative stress-related conditions necessitates the development of multifunctional therapeutic agents. The main objectives of this investigation is synthesis, characterization, and biomedical assessment of silver nanoparticles (AgNPs) synthesized via a modified Turkevich method using trisodium citrate and SDS as reducing and capping agents. Characterization through ultraviolet–visible (UV–Vis) spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, zeta potential analysis, and field-emission scanning electron microscopy (FE-SEM) confirmed the successful formation of stable, spherical AgNPs with sizes ranging from 21.99 to 41.35 nm and a moderately stable surface charge (− 27.24 mV). Biological evaluations demonstrated the dose-dependent cytotoxicity of AgNPs against A375 melanoma skin cancer cells, with significant reduction in cell viability at higher concentrations. Antibacterial assessment against Staphylococcus aureus (S. aureus) revealed strong, concentration-dependent inhibition zones, highlighting the AgNPs potential in combating resistant skin infections. Additionally, AgNPs exhibited noteworthy antioxidant activity in DPPH assays, although slightly lower than standard ascorbic acid. The results suggest that the synthesized AgNPs possess potent triple-functional activity, including anticancer, antibacterial, and antioxidant activity, supporting their applicability in integrated therapeutic strategies for skin-related conditions.

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银纳米粒子作为一种三重作用剂：治疗皮肤癌、皮肤感染和抗氧化活性的潜力

皮肤癌、抗菌素耐药性和氧化应激相关疾病的发病率不断增加，需要开发多功能治疗剂。本研究的主要目的是利用柠檬酸三钠和SDS作为还原和封盖剂，通过改进的Turkevich方法合成银纳米颗粒（AgNPs）的合成、表征和生物医学评估。通过紫外-可见（UV-Vis）光谱、x射线衍射（XRD）、傅里叶变换红外（FT-IR）光谱、zeta电位分析和场发射扫描电镜（FE-SEM）表征，证实成功形成了稳定的球形AgNPs，尺寸在21.99 ~ 41.35 nm之间，表面电荷（- 27.24 mV）较为稳定。生物学评估表明AgNPs对A375黑色素瘤皮肤癌细胞具有剂量依赖性的细胞毒性，高浓度时细胞活力显著降低。对金黄色葡萄球菌（S. aureus）的抗菌评估显示出强烈的浓度依赖性抑制带，突出了AgNPs在对抗耐药皮肤感染方面的潜力。此外，AgNPs在DPPH试验中表现出显著的抗氧化活性，尽管略低于标准抗坏血酸。结果表明，合成的AgNPs具有强大的三功能活性，包括抗癌、抗菌和抗氧化活性，支持其在皮肤相关疾病的综合治疗策略中的适用性。

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来源期刊

Applied Nanoscience Materials Science-Materials Science (miscellaneous)

CiteScore

7.10

自引率

0.00%

发文量

430

期刊介绍： Applied Nanoscience is a hybrid journal that publishes original articles about state of the art nanoscience and the application of emerging nanotechnologies to areas fundamental to building technologically advanced and sustainable civilization, including areas as diverse as water science, advanced materials, energy, electronics, environmental science and medicine. The journal accepts original and review articles as well as book reviews for publication. All the manuscripts are single-blind peer-reviewed for scientific quality and acceptance.