Electrochemical Carboxylative Cyclization of Propargylamines with CO2 to Functionalized 2-Oxazolidinones

Abstract

The electrochemical conversion of CO₂ into value-added chemicals represents a promising strategy for sustainable synthesis. Herein, we report a novel electrochemical carboxylative cyclization of propargylamines with CO₂ to access exocyclic iodo-carboxyl-vinylene 2-oxazolidinones bearing two CO₂ moieties by using tetraethylammonium iodide (Et₄NI) as both the electrolyte and the “iodine source”, which enables the one-pot construction of C–O, C–C, C–N, and C–I bonds. The protocol proceeds under mild conditions and accommodates a broad range of substrates, providing access to functionalized 2-oxazolidinones with high structural complexity.