Preoperative prediction of Glypican-3 in hepatocellular carcinoma by two-dimensional ultrasound, contrast-enhanced ultrasound and microflow imaging.

Yingtan Zhang, Ran Liu, Peipei Li, Xiao Chen, Jiesi Zhang, Qiujie Yu, Li Li
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Abstract

ObjectiveTo explore the preoperative predictive efficacy of multimodal ultrasound based on microflow imaging(MFI) in Glypican-3(GPC-3) in hepatocellular carcinoma(HCC).MethodsThe general data and ultrasonographic data of patients with HCC confirmed by histopathology and hepatectomy from January 2019 to June 2023 were analyzed retrospectively. According to the gold standard of postoperative pathology, the patients were divided into GPC-3 positive group and GPC-3 negative group. Through analyze the correlation between multimodal ultrasound features and GPC-3, to determine the independent predictors of GPC-3, and to further analyze the preoperative predictive efficiency of Two-dimensional ultrasound(2D-US), contrast-enhanced ultrasound(CEUS) and microflow imaging(MFI) for GPC-3 of HCC.ResultsA total of 102 patients were enrolled in this study, including 60 GPC-3 positive patients(58.8%) and 42 GPC-3 negative patients(41.2%). Through univariate and multivariate analysis, it was found that there were significant differences in diameter(95%CI: 1.080-7.741, P = 0.034), start washout time(95%CI: 0.105-0.694, P = 0.007) and CEUS-MFI(95%CI: 1.180-4.553, P = 0.015) between the two groups, which were independent predictors of GPC-3 positive occurrence. The prediction efficiency of multimodal ultrasound combined with GPC-3 for HCC is better than that of single mode(P<0.05).ConclusionThe feasibility of multimodal ultrasound in predicting GPC-3 of HCC before operation is confirmed.

术前二维超声、超声增强及微血流显像预测Glypican-3在肝癌中的应用
目的探讨术前基于微流成像(MFI)的多模态超声对肝细胞癌(HCC) Glypican-3(GPC-3)的预测作用。方法回顾性分析2019年1月至2023年6月经组织病理学和肝切除术证实的肝癌患者的一般资料和超声资料。按照术后病理金标准将患者分为GPC-3阳性组和GPC-3阴性组。通过分析多模态超声特征与GPC-3的相关性,确定GPC-3的独立预测因素,进一步分析术前二维超声(2D-US)、增强超声(CEUS)、微流成像(MFI)对GPC-3 HCC的预测效果。结果共纳入102例患者,其中GPC-3阳性60例(58.8%),GPC-3阴性42例(41.2%)。通过单因素和多因素分析发现,两组间直径(95%CI: 1.080 ~ 7.741, P = 0.034)、开始洗脱时间(95%CI: 0.105 ~ 0.694, P = 0.007)和CEUS-MFI(95%CI: 1.180 ~ 4.553, P = 0.015)差异有统计学意义,均为GPC-3阳性发生的独立预测因子。多模态超声联合GPC-3对HCC的预测效率优于单模态(P
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